复方血栓通胶囊联合玻璃体腔内注射康柏西普治疗糖尿病患者白内障术后临床研究  

Clinical Study on Compound Xueshuantong Capsules Combined with Intravitreal Injection of Conbercept for Diabetic Patients after Cataract Surgery

作　　者：蒋骁男 李世洋 肖建和 JIANG Xiaonan;LI Shiyang;XIAO Jianhe

机构地区：[1]中国人民解放军联勤保障部队第九八九医院,河南洛阳471000

出　　处：《新中医》2020年第8期91-93,共3页New Chinese Medicine

摘　　要：目的:观察复方血栓胶囊通联合玻璃体腔内注射康柏西普对糖尿病患者白内障术后黄斑水肿的影响。方法:将成功行白内障超声乳化摘除手术后3个月,确诊发生黄斑水肿的糖尿病者148例(148眼),随机分为对照组和观察组,每组各74例(74眼);2组患者均注射康柏西普,观察组患者同时口服复方血栓通胶囊;观察2组治疗前和治疗后1、2、3个月最佳矫正视力(BCVA)、黄斑中心凹视网膜厚度(CMT)变化,同时记录不良反应情况。结果:治疗后1、2、3个月,2组患者BCVA值均较治疗前升高(P<0.05);且观察组各个时点的BCVA值均高于对照组(P<0.05)。治疗后1、2、3个月,2组患者CMT值均较治疗前降低(P<0.05);且观察组各个时点的CMT值均低于对照组(P<0.05)。在治疗中2组患者均无与治疗药物相关的不良反应。结论:玻璃体腔内注射康柏西普结合复方血栓通应用,可显著减轻糖尿病者白内障术后黄斑水肿,有效改善患者视力水平。Objective:To observe the effect of compound Xueshuantong capsules combined with intravitreal injection of conbercept on macular edema in diabetic patients after cataract surgery.Methods:A total of 148 cases of diabetic patients(148 eyes)were diagnosed as macular edema three months after successful phacoemulsification,and were randomly divided into the control group and the treatment group,74 cases(74 eyes)in each group.Both groups were given injection of conbercept,and the observation group was additionally treated with oral administration of compound Xueshuantong capsules.The changes in the Best Corrected Visual Acuity(BCVA)and Central Macular Thickness(CMT)before treatment and in the 1st,2nd and 3rd month after treatment were observed in the two groups;the adverse reactions were recorded.Results:In the 1st,2nd and 3rd month after treatment,the values of BCVA in the two groups were increased when compared with those before treatment(P<0.05),and the value at each time point in the observation group was higher than that in the control group(P<0.05).In the 1st,2nd and 3rd month after treatment,the CMT in the two groups were decreased when compared with those before treatment(P<0.05),and the value at each time point in the observation group was lower than that in the control group(P<0.05).During treatment,there was no adverse reaction related to the medication in the two groups.Conclusion:The therapy of intravitreal injection of conbercept combined with compound Xueshuantong capsules can significantly decrease macular edema in diabetic patients after cataract surgery,and effectively improve their visual acuity.

关 键 词：白内障术后 黄斑水肿 糖尿病 康柏西普 复方血栓通胶囊 

分 类 号：R776.1[医药卫生—眼科]