外用溃疡散联合LEEP术治疗宫颈上皮内瘤变临床研究  

Clinical Study on Waiyong Kuiyang San Combined with Loop Electrosurgical Excision Procedurefor Cervical Intraepithelial Neoplasia

作　　者：张卫丹 程亚丽 张琼 ZHANG Weidan;CHENG Yali;ZHANG Qiong

机构地区：[1]台州医院恩泽妇产医院妇产科,浙江台州318000 [2]台州恩泽医疗中心(集团)恩泽医院妇科,浙江台州318025 [3]玉环市第二人民医院中医科,浙江玉环317605

出　　处：《新中医》2020年第8期116-118,共3页New Chinese Medicine

摘　　要：目的:观察外用溃疡散联合LEEP刀手术治疗宫颈上皮内瘤变(CIN)的临床疗效。方法:将CIN患者130例随机分为对照组与治疗组,每组65例;对照组给予LEEP刀宫颈锥切术治疗,治疗组采取LEEP刀手术联合外用溃疡散治疗;观察比较2组手术前后症状体征(包括糜烂面积、阴道清洁度、白带性质)评分;术后阴道流血、阴道流液及创面愈合时间;术后并发症发生情况与临床总体疗效。结果:总有效率治疗组为92.31%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者糜烂面积、阴道清洁度、白带性质评分均较治疗前降低(P<0.05);且治疗组各项评分均明显低于对照组(P<0.05)。治疗后,治疗组术后阴道流血、阴道流液量均明显少于对照组(P<0.05),创面愈合时间短于对照组(P<0.05)。术后并发症发生率治疗组为3.08%,对照组为15.38%,2组比较,差异有统计学意义(P<0.05)。结论:与单独使用LEEP刀宫颈锥切术治疗CIN比较,术后配合外用溃疡散疗效肯定,可更好地改善患者临床症状体征,缩短术后出血与创面愈合时间,减少术后并发症,值得临床推广应用。Objective:To observe the clinical effect of Waiyong Kuiyang San combined with loop electrosurgical excision procedure(LEEP)for cervical intraepithelial neoplasia(CIN).Methods:A total of 130 cases of CIN patients were randomly divided into the control group and the treatment group,65 cases in each group.The control group was treated with cervical conization by LEEP knife,and the treatment group was treated with LEEP combined with Waiyong Kuiyang San.The scores of symptoms and signs including erosive area,vaginal cleanliness and leucorrhea before and after surgery,the time of vaginal bleeding,vaginal fluid and wound healing after surgery,postoperative complications and total clinical effect in the two groups were observed and compared.Results:The total effective rate was 92.31%in the treatment group and 80.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of erosive area,vaginal cleanliness and leucorrhea in the two groups were all decreased when compared with those before treatment(P<0.05),and the above scores in the treatment group were significantly lower than those inthe control group(P<0.05).After treatment,the amount of postoperative vaginal bleeding and vaginal fluid in the treatment group was significantly lower than that in the control group(P<0.05),and the wound healing time was shorter than that in the control group(P<0.05).The incidence of postoperative complications was 3.08%in the treatment group and 15.38%in the control group,the difference being significant(P<0.05).Conclusion:Compared with the simple treatment of cervical conization by LEEP knife,the additional application ofWaiyong Kuiyang San has definite curative effect,which can better improve the clinical symptoms and signs of patients,shorten the time of postoperative bleeding and wound healing,and reduce postoperative complications,and it is worthy of clinical promotion and application.

关 键 词：宫颈上皮内瘤变 外用溃疡散 LEEP 宫颈锥切术 

分 类 号：R737.33[医药卫生—肿瘤]