吲哚美辛栓与生长抑素的应用对胆总管结石内镜下治疗术后并发胰腺炎预防效果的临床对比研究  

Comparison of the Effect of Indomethacin Suppository and Somatostatin on the Prevention of Pancreatitis after Endoscopic Treatment of Choledocholithiasis

作　　者：周华[1] ZHOU Hua(Zibo Central Hospital,Zibo 255000,China)

机构地区：[1]淄博市中心医院,山东淄博255000

出　　处：《中国医药指南》2020年第14期135-136,共2页Guide of China Medicine

摘　　要：目的对比研究吲哚美辛栓与生长抑素的应用对胆总管结石内镜下治疗术后并发胰腺炎的预防效果。方法选择2016年2月至2018年2月在我院行胆总管结石内镜下治疗术的90例患者为观察对象,随机分组,甲组给予吲哚美辛栓,乙组给予生长抑素,丙组给予安慰剂,对比三组预防效果。结果术后甲组、乙组患者血清淀粉酶、C反应蛋白水平低于丙组,对比有统计意义,P<0.05,甲乙两组患者血清淀粉酶、C反应蛋白水平对比无统计意义,P>0.05;甲、乙两组患者高淀粉酶血症、胰腺炎出现概率低于丙组,住院时间比丙组短,对比有统计意义,P<0.05;甲、乙两组患者高淀粉酶血症、胰腺炎出现概率、住院时间对比无统计意义,P>0.05。结论吲哚美辛栓与生长抑素对胆总管结石内镜下治疗术后并发胰腺炎预防效果均较优。Objective To compare the effect of indomethacin suppository and somatostatin on the prevention of postoperative pancreatitis after endoscopic treatment of choledocholithiasis.Methods A total of 90 patients undergoing endoscopic treatment for choledocholithiasis in our hospital from February 2016 to February 2018 were selected as subjects for observation.They were randomly divided into three groups:indomethacin was given to group A,somatostatin was given to group B,and placebo was given to group C.Results The levels of serum amylase and c-reactive protein in patients of group A and group B were lower than that of group C,and the comparison was statistically significant.The probability of hyperamylasemia and pancreatitis in group A and group B was lower than that in group C,and the length of stay was shorter than that in group C,showing statistical significance,P<0.05.There was no statistical significance of hyperamylasemia,incidence rate of pancreatitis and length of hospital stay in both groups,P>0.05.Conclusion Both indomethacin and somatostatin are effective in preventing pancreatitis after endoscopic treatment of choledocholithiasis.

关 键 词：吲哚美辛栓 生长抑素 胆总管结石内镜 胰腺炎 

分 类 号：R576[医药卫生—消化系统] R575.6+2[医药卫生—内科学]