T细胞/组织细胞丰富的大B细胞淋巴瘤病理学诊断特征分析  

Pathological diagnostics of T-cell/histiocyte-rich large B-cell lymphoma

作　　者：刘双[1] 班媛媛[2] 李道胜[3] Liu Shuang;Ban Yuanyuan;Li Daosheng(Department of Hematology,The Central Hospital of Tai'an,Tai'an 271000,China;Department of Gerontology,The Central Hospital of Tai'an,Tai'an 271000,China;Department of Pathology,The Central Hospital of Tai'an,Tai'an 271000,China)

机构地区：[1]泰安市中心医院血液内科,271000 [2]泰安市中心医院老年病一科,271000 [3]泰安市中心医院病理科,271000

出　　处：《中华临床医师杂志（电子版）》2020年第1期43-47,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨T细胞/组织细胞丰富的大B细胞淋巴瘤的病理诊断学特征。方法回顾性分析12例2010年1月至2017年12月经泰安市中心医院病理科确诊的T细胞/组织细胞丰富的大B细胞淋巴瘤患者的临床资料,观察T细胞/组织细胞丰富的大B细胞淋巴瘤的病理形态学特点及免疫表型。结果患者男性7例,女性5例,年龄46~78岁;光镜下均可见淋巴结正常结构破坏,在小淋巴细胞和数量不等的组织细胞的背景下,散在单个大细胞;免疫组化显示大细胞CD20阳性,小淋巴细胞CD3阳性。结论T细胞/组织细胞丰富的大B细胞淋巴瘤是一种相对少见的淋巴瘤,以在小T淋巴细胞和数量不等的组织细胞的背景下散在一定数量的不典型大B细胞为特征;临床及组织学表现均易与其他类型的淋巴瘤相混淆,掌握其共同的特征并结合免疫组化方能正确诊断。Objective To explore the pathological diagnostics of T-cell/histiocyte-rich large B-cell lymphoma(THRLBCL).Methods A retrospective analysis was performed on the clinical data of 12 cases of THRLBCL diagnosed at the Department of Pathology of Tai'an Central Hospital from January 2010 to December 2017.Hematoxylin and eosin staining,immunohistochemistry,and histochemistry were performed on the archival paraffin sections.Results Amongst the 12 patients studied,7 were male and 5 were female.Their age at the time of operation ranged from 46 to 78 years.Under a light microscope,the normal structure of lymph nodes was destroyed.In the background of small lymphocytes and a variable number of tissue cells,single large cells were scattered.Immunohistochemistry showed positive CD20 staining in large cells and positive CD3 staining in small lymphocytes.Conclusion THRLBCL is a relatively rare form of lymphoma that is characterized by some atypical large B cells scattered in the background of small T cell lymphocytes and a variable number of tissue cells.It is similar to other types of lymphoma with regard to clinical manifestations,imaging findings,and histology.A thorough understanding of their clinical features in combination with immunohistochemical results is helpful in arriving at the correct diagnosis.

关 键 词：T细胞/组织细胞丰富的大B细胞淋巴瘤 免疫组织化学 病理诊断学 

分 类 号：R733.1[医药卫生—肿瘤]