双相障碍患者NLR、PLR、MLR及非酶类抗氧化物的临床研究  

Clinical Study of Bipolar Disorder on Inflammatory Markers NLR,PLR,MLR and Non-enzyme Antioxidants

作　　者：常少华 方建群[2] CHANG Shaohua;FANG Jianqun(School of Clinical Medicine,Ningxia Medical University,Yinchuan 750004,China;Department of Psychiatry,the General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学临床医学院,银川750004 [2]宁夏医科大学总医院心理卫生中心,银川750004

出　　处：《宁夏医科大学学报》2020年第2期140-144,共5页Journal of Ningxia Medical University

摘　　要：目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrophil to lymphocyteratio,NLR)、血小板计数与淋巴细胞计数的比值(platelet to lymphocyteratio,PLR)、单核细胞计数与淋巴细胞计数的比值(monocyte to lymphocyte ratio,MLR)及血胆红素、白蛋白、尿酸水平;采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和杨氏躁狂量表(Young mania rating scale,YMRS)评估两组被试者的抑郁症状及躁狂症状;分析HAMD、YMRS量表评分与各指标之间的关系。结果与健康对照组比较,双相障碍组血尿酸、MLR升高,白蛋白水平降低(P均<0.05)。HAMD和YMRS量表评分与白蛋白呈负相关(r=-0.410、-0.462,P均<0.05),与MLR呈正相关(r=0.353、0.455,P均<0.05)。血尿酸水平与YMRS量表评分呈正相关(r=0.346,P<0.05)。结论炎症指标MLR和非酶类抗氧化物白蛋白、血尿酸水平有助于急性期双相障碍的临床评估。Objective To investigate the relationship between inflammatory markers and non-enzymatic antioxidants and the severity of clinical symptoms in patients with acute bipolar disorder.Methods Totally 80 patients with acute bipolar disorder(bipolar disorder group)and 80 healthy subjects(healthy control group)were selected as subjects.The neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR),serum bilirubin,albumin and uric acid levels of the groups were tested.The Hamilton Depression Scale(HAMD)and the Young Mania Rating Scale(YMRS)were used to evaluate the depressive and mania symptoms of two groups of subjects.The relationship between the scores of HAMD and YMRS scale and each index was analyzed.Results Compared with healthy control group,the serum uric acid level and MLR in bipolar disorder group increased,while the serum albumin level decreased(P all<0.05).HAMD and YMRS scale scores were negatively correlated with albumin levels(r=-0.410,-0.462,P all<0.05),and positively correlated with MLR(r=0.353,0.455,P<0.05).Serum uric acid level was positively correlated with YMRS scale score(r=0.346,P<0.05).Conclusion The inflammatory markers MLR,non-enzymatic antioxidant albumin and serum uric acid are helpful for clinical evaluation of acute bipolar disorder.

关 键 词：NLR PLR MLR 非酶类抗氧化物 双相障碍 

分 类 号：R749.3[医药卫生—神经病学与精神病学]