伊托必利、奥美拉唑联合He-Ne激光治疗反流性食管炎的疗效及对患者焦虑抑郁的影响  

Efficacy of Itopride and Omeprazole Combined with He-Ne Laser in the Treatment of Reflux Esophagitis and the Impacts on Anxiety and Depression in Patients

作　　者：郑世红 杨周静 ZHENG Shihong;YANG Zhoujing(Department of Digestive Medicine,The Fourth People’s Hospital of Langfang,Langfang 065700,Hebei,P.R.China;Department of Cardiology,The Third Hospital of Bazhou,Langfang 065700,Hebei,P.R.China)

机构地区：[1]廊坊市第四人民医院消化内科,河北廊坊065700 [2]霸州市第三医院心内科,河北廊坊065700

出　　处：《影像科学与光化学》2020年第3期566-571,共6页Imaging Science and Photochemistry

摘　　要：本文研究了伊托必利、奥美拉唑联合He-Ne激光治疗反流性食管炎的效果及对患者焦虑抑郁状态的影响。将112例反流性食管炎患者随机分为观察组和对照组,每组各56例。对照组给予伊托必利联合奥美拉唑治疗,观察组在对照组用药基础上加用He-Ne激光照射治疗。比较两组治疗的总有效率,观察两组患者治疗前后食管黏膜胃镜分级、胃肠激素和细胞因子水平、焦虑抑郁状况及生活质量的变化。结果显示,观察组治疗总有效率(94.64%)高于对照组(79.07%)(P<0.05)。两组治疗后胃镜黏膜分级均明显改善,胃动素血清水平及SF-36评分增高,血清中血管活性肠肽、5-羟色胺、白细胞介素-17、白细胞介素-23水平及SAS、SDS评分下降(P<0.05),但观察组改善情况优于对照组(P<0.05)。结果表明,伊托必利、奥美拉唑联合He-Ne激光治疗反流性食管炎的疗效良好,可有效修复食管黏膜损伤,改善患者炎症和焦虑抑郁状态,提高生活质量。In this paper,the efficacy of Itopride and Omeprazole combined with He-Ne laser in the treatment of reflux esophagitis and impacts on anxiety and depression in patients were studied.112 patients suffering from reflux esophagitis were randomly divided into observation group and control group,with 56 cases each.The control group received Itopril combined with Omeprazole,and the observation group received He-Ne laser irradiation on the basis of the control group.The total effective rates were compared between the two groups.The changes of esophageal mucosal gastroscopy grading,serum concentrations of gastrointestinal hormones and cytokines,anxiety and depression,and quality of life before and after treatment were observed between the two groups.The results showed that the total effective rate(94.64%)in the observation group was higher than that in the control group(79.07%)(P<0.05).After treatment,endoscopic mucosal grading was significantly improved in both groups,motilin serum level and SF-36 score were increased,and serum concentrations of vasoactive intestinal peptide,5-hydroxytryptamine,interleukin-17,interleukin-23,SAS and SDS scores were decreased(P<0.05),but the improvement in the observation group was better than that in the control group(P<0.05).The results indicate that Itopride and Omeprazole combined with He-Ne laser for the treatment of reflux esophagitis have a good effect,which can effectively repair esophageal mucosal injury,suppress inflammation,ease anxiety and depression,and improve quality of life.

关 键 词：反流性食管炎 伊托必利 奥美拉唑 HE-NE激光 炎症 焦虑 抑郁 生活质量 

分 类 号：R571[医药卫生—消化系统]