康柏西普或雷珠单抗联合激光治疗BRVO合并黄斑水肿的效果比较  

Comparison of the Effect of Conbercept or Rapunzumab Combinedwith Laser in the Treatment of BRVO with Macular Edema

作　　者：宋清雪 马鹤 SONG Qingxue;MA He(Liaoyang Central Hospital,Liaoning Liaoyang 111000,China)

机构地区：[1]辽宁省辽阳市中心医院眼科,辽宁辽阳111000

出　　处：《河北医学》2020年第5期713-717,共5页Hebei Medicine

基　　金：辽宁省科学技术计划项目,(编号:2016241030)。

摘　　要：目的:探讨康柏西普或雷珠单抗联合激光治疗视网膜分支静脉阻塞(BRVO)合并黄斑水肿的效果,分析视力与黄斑中心凹厚度(CMT)、视网膜外核层厚度(ONLT)的关系。方法:选取我院2016年3月至2019年6月在我院治疗的BRVO合并黄斑水肿患者89例(89眼)作为研究对象,随机分为观察组(45例45眼)和对照组(44例44眼),观察组采用康柏西普联合眼底激光治疗,对照组采用雷珠单抗联合眼底激光治疗。观察两组最佳矫正视力(BCVA)、CMT、ONLT及及黄斑区渗漏状况。分析BCVA与CMT及ONLT的关系。结果:经重复测量数据方差分析,结果显示BCVA在不同时间及组间与时间交互作用上差异有统计学意义(P<0.05),在组间无统计学意义(P>0.05);CMT、ONLT在不同时间上差异有统计学意义(P<0.05),在组间上及组间与时间交互作用上均无统计学意义(P>0.05)。两组CMT、ONLT随治疗后时间延长有降低趋势,BCVA有升高趋势,治疗后不同时间点CMT、ONLT均低于治疗前,BCVA均高于治疗前(P<0.5)。观察组治疗后1、2、3个月BCVA高于对照组,观察组治疗后3个月CMT低于对照组,观察组治疗后2、3个月ONLT低于对照组,差异有统计学意义(P<0.05)。结论:康柏西普联合眼底激光治疗在BRVO合并黄斑水肿患者视力改善、抑制黄斑水肿效果优于雷珠单抗联合眼底激光治疗,且安全性高。Objective:To investigate the effect of conbercept or laser in the treatment of branch retinal vein occlusion(BRVO)with macular edema,and to analyze the relationship between visual acuity and the central macular thickness(CMT)and the outer nuclear layer thickness(ONLT).Methods:89 cases(89 eyes)of BRVO patients with macular edema treated in our hospital from March 2016 to June 2019 were randomly divided into the observation group(45 cases and 45 eyes)and the control group(44 cases and 44 eyes).The observation group was treated with conbercept and fundus laser,and the control group was treated with leizhumab and fundus laser.BCVA,CMT,ONLT and macular leakage were observed.the relationship between BCVA,CMT andONLT were analyzed.Results:There was significant difference in BCVA at different time and time interaction between groups(P<0.05),but no significant difference between groups(P>0.05).CMT and ONLT had significant difference in different time(P<0.05),but no significant difference in the interaction between groups and time(P>0.05).The CMT and ONLT of the two groups decreased with the time after treatment,and BCVA increased.The CMT and ONLT of the two groups were lower than before treatment at different time points after treatment,and BCVA was higher than before treatment(P>0.05).The BCVA of the observation group was higher than that of the control group at 1,2 and 3 months after treatment,the CMT of the observation group was lower than that of the control group at 3 months after treatment,and the ONLT of the observation group was lower than that of the control group at 2 and 3 months after treatment(P<0.05).Conclusion:The effect of conbercept combined with fundus laser in BRVO patients with macular edema is better than that of leizhumab combined with fundus laser.It has high security.

关 键 词：视网膜分支静脉阻塞 康柏西普 雷珠单抗 激光治疗 黄斑水肿 

分 类 号：R774[医药卫生—眼科]