大剂量干扰素辅助治疗口腔黏膜恶性黑色素瘤的效果及安全性研究  

Effect and safety of high-dose interferon in the treatment of malignant melanoma of oral mucosa

作　　者：丛琳[1] CONG Lin(Department of Stomatology,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院口腔科,黑龙江佳木斯154002

出　　处：《中国现代医生》2020年第8期65-67,共3页China Modern Doctor

摘　　要：目的研究大剂量干扰素辅助治疗口腔黏膜恶性黑色素瘤的临床效果,探讨治疗应用的安全性。方法选取我院于2017年11月~2018年11月收治的80例口腔黏膜恶性黑色素瘤患者作为研究对象,按照治疗方法不同分为两组,每组40例。对照组患者仅采用单纯手术治疗,治疗组在此基础上采用大剂量干扰素辅助治疗。观察两组患者生存情况、疾病复发情况以及毒副反应。结果治疗组患者生存期限及无复发生存期明显长于对照组,治疗组复发率为5.00%,明显低于对照组的22.50%,差异有统计学意义(P<0.05)。两组患者毒副反应比较差异无统计学意义(P>0.05)。结论口腔黏膜恶性黑色素瘤患者予以大剂量干扰素辅助疗法安全有效,值得临床推广。Objective To study the clinical effect of high-dose interferon in the treatment of malignant melanoma of oral mucosa and to explore the safety of therapeutic application. Methods Eighty patients with oral mucosal malignant melanoma admitted to our hospital from November 2017 to November 2018 were enrolled in this study. They were divided into two groups according to different treatment methods, with 40 cases in each group. The patients in the control group were treated with surgery alone, and the treatment group was treated with high-dose interferon based on the above treatment. The survival, recurrence and side effects of the two groups were observed. Results The survival period and recurrence-free survival of the treatment group were significantly longer than those of the control group. The recurrence rate in the treatment group(5.00%) was significantly lower than that of the control group(22.50%), and the differ ence was statistically significant(P<0.05). There was no significant difference in toxicity between the two groups(P>0.05).Conclusion High-dose interferon adjuvant therapy for patients with oral mucosal malignant melanoma is safe and effective. It is worthy of clinical promotion.

关 键 词：口腔黏膜 恶性黑色素瘤 干扰素 治疗效果 安全性 临床研究 

分 类 号：R739.8[医药卫生—肿瘤]