Synthesis of Intermediate N-Chloroformyl-N-[4-(trifluoromethoxy)phenyl]Methyl Carbamate of Indoxacarb  

作　　者：Zhang Zhenming Kong Xianbin Wang Gang Wang Xiaohui Liu Minjin 

机构地区：[1]Jiangsu Changqing Agrochemical Co.,Ltd.,Yangzhou 225000,China [2]Shenyang Research Institute of Chemical Industry Co.,Ltd.,Shenyang 110021,China

出　　处：《Plant Diseases and Pests》2020年第1期36-40,共5页植物病虫害研究（英文版）

摘　　要：[Objective]The paper was to study a synthetic method suitable for industrial production of intermediate N-Chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl carbamate of indoxacarb.[Method]Using 4-trifluoromethoxy aniline as the starting material,[4-(trifluoromethoxy)phenyl]carbamate was synthesized by homogeneous formylation method without acid-binding agent.Subsequently,it was reacted with sodium methoxide/potassium methoxide by reactive distillation to obtain[4-(trifluoromethoxy)phenyl]carbamate ammonium sodium/potassium,then directly reacted with triphosgene to obtain crude products of N-carbonochloridoyl-N-[4-(trifluoromethoxy)phenyl]carbamate;finally,competing product was obtained by recrystallization.[Result]The intermediate N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]carbamate was synthesized by the method.The content of products was higher than 98%.The yield of product reached above 96%(calculated by 4-trifluoromethoxy aniline).[Conclusion]The method used for the synthesis of intermediate N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl carbamate was simple,with less three wastes,higher safety and lower cost.

关 键 词：INDOXACARB INTERMEDIATE N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl CARBAMATE Synthesis Sodium/potassium ammonium salt FORMYLATION Recrystallization 

分 类 号：TQ453[化学工程—农药化工]