前额无色素性黑素瘤一例  

Amelanotic melanoma on the forehead:a case report

作　　者：杨静[1] 蔡梅[1] 周晓鸿[1] 熊臻 YANG Jing;CAI Mei;ZHOU Xiaohong;XIONG Zhen(Department of Dermatology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院,昆明650101

出　　处：《中国麻风皮肤病杂志》2020年第5期289-292,共4页China Journal of Leprosy and Skin Diseases

摘　　要：患者,女,72岁。右侧额部包块1年,术后复发1个月。组织病理示:表皮基底层色素细胞增生活跃,真皮全层可见肿瘤细胞呈巢状分布,细胞异型明显,可见核分裂象。免疫组化示S100(+)。基因检测示:PD-L1免疫组化阳性(10.00%);BRAF基因无突变。诊断:黑素瘤。给予PD-1/PD-L1靶向阻断药物可瑞达治疗6个疗程,包块仍在扩大并右眼失明。A 72-year-old female presented with malignant mass on the right forehead for one year and relapsed for one month.Biopsy showed an active proliferation of melanocytes,clustered together in the dermis with proliferation of atypical melanocytes.Immunohistochemistry revealed S100-positive within the dermis.Genetic testing showed that PD-L1 immunohistochemistry was positive by 10.00%and no mutation was found in the BRAF gene.The diagnosis of melanoma was made.The patient was treated with Keytruda,PD-1/PD-L1 targeted blocker drug for 6 courses,but the lump was still expanding and the patient lost vision in her right eye.

关 键 词：无色素黑素瘤 

分 类 号：R739.5[医药卫生—肿瘤]