肝源性溃疡与幽门螺杆菌关系研究  

Study on the correlation between hepatogenic ulcer and Helicobacter pylori

作　　者：乔冠恩[1] 孔洪彬 王敏[3] 李亮亮 朱琳[1] 董魁[1] 张文娟[1] 马立东 QIAO Guan-en;KONG Hong-bin;WANG Min(Department of Gastroenterology,Handan First Hospital,Handan 056000,China)

机构地区：[1]邯郸市第一医院消化科,056000 [2]邯郸市传染病医院肝七科,056000 [3]邯郸市中心医院感染科,056000 [4]邯郸市成安县中医院内科,056000

出　　处：《中国实用医药》2020年第12期23-25,共3页China Practical Medicine

摘　　要：目的研究肝源性溃疡(HU)患者幽门螺杆菌(Hp)感染情况及影响因素。方法选取确诊的80例HU患者作为HU组,80例肝硬化无消化性溃疡患者作为肝硬化无溃疡组,80例功能性消化不良(FD)患者作为FD组,通过快速尿素酶试验(RUT)或14C尿素呼气试验来判断Hp感染。比较三组患者Hp阳性情况;不同肝功能分级、不同食管静脉曲张程度HU患者Hp阳性情况。结果HU组患者Hp阳性率为80.00%,明显高于肝硬化无溃疡组的60.00%、FD组的43.75%,差异具有统计学意义(P<0.05)。80例HU患者中,肝功能A级患者Hp阳性率为79.17%(38/48),与肝功能B级的81.25%(26/32)比较差异无统计学意义(P>0.05)。80例HU患者中,轻度食管静脉曲张患者Hp阳性率为88.89%(40/45),高于中重度食管静脉曲张患者的68.57%(24/35),差异有统计学意义(P<0.05)。结论HU患者有较高的Hp感染率,Hp感染是HU患者发病原因之一,且Hp感染与HU患者门脉压有关,与肝功能分级无关。Objective To study Helicobacter pylori(Hp)infection and its influencing factors in patients with hepatogenic ulcer(HU).Methods There were 80 confirmed HU patients selected as the HU group,80 patients with cirrhosis without peptic ulcers as the cirrhosis without ulcers group,and 80 patients with functional dyspepsia(FD)as the FD group.HP infection was determined by rapid urease test(RUT)or 14 C urea breath test.The Hp-positive status and Hp-positive status of HU patients with different liver function grades and different degrees of esophageal varices were compared among three groups of patients.Results The Hp-positive rate of HU group was 80.00%,which was obviously higher than that of cirrhosis without ulcers group 60.00%and FD group 43.75%,and the difference was statistically significant(P<0.05).In 80 HU patients,the HP-positive rate was 79.17%(38/48)in patients with grade A liver function,and there was no statistically significant difference compared with 81.25%(26/32)in patients with grade B liver function(P>0.05).In 80 HU patients,the HP-positive rate of mild esophageal varices was 88.89%(40/45),which was higher than that of moderate and severe esophageal varices 68.57%(24/35),and the difference was statistically significant(P<0.05).Conclusion There is a in HU patients.Hp infection is one of the causes of HU patients,and Hp infection is correlated with portal pressure in HU patients and has nothing to do with liver function grades.

关 键 词：肝源性溃疡 发病机制 幽门螺杆菌 

分 类 号：R573.1[医药卫生—消化系统] R575.2[医药卫生—内科学]