G蛋白偶联受体MrgprD研究进展及对中医药研究的启示  

Research Progress of GProtein Coupled Receptor MrgprD and its Implications for the Research of Chinese Medicine

作　　者：王地均 金香 唐宗湘[1] 王长明[1] WANG Di-jun;JIN Xiang;TANG Zong-xiang;WANG Chang-ming(School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China)

机构地区：[1]南京中医药大学医学院·整合医学院,江苏南京210023

出　　处：《南京中医药大学学报》2020年第3期419-423,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81600966);江苏省自然科学基金(BK20161042)。

摘　　要：中医药在止痒、镇痛方面具有副作用小、疗效明确的优势,但是其作用的分子生物学机制并不清楚。MrgprD(Mas-related gene D)是G蛋白偶联受体Mrg(Mas-related genes)家族的一个成员,特异表达于外周初级感觉神经元上。综述了MrgprD近20年的研究现状,为认识MrgprD的新功能并为相关疾病治疗提供参考。鉴于MrgprD在痛觉和痒觉产生中的作用,可能成为中医药镇痛、止痒的作用靶点,为中医药的研究提供思考。Traditional Chinese medicine has the advantages of small side effects and clear curative effect in relieving itching and analgesia,but the molecular biological mechanisms are not clear.MrgprD(Mas-related gene D)is a member of the G-protein coupled receptor and is mainly expressed on peripheral primary sensory neurons.The study revealed the mechanism of involvement of MrgprD in neuropathic pain and discussed the relationship between itch and pain.Based on our own research results,we reviewed the current research status of MrgprD in recent decades.This review could provide a reference for the understanding of the function of MrgprD and the treatment of related diseases.Additionally,MrgprD may be the targets of antipruritic and analgesic Chinese herb and provide a new idea for the research of Chinese medicine.

关 键 词：MrgprD DRG 痛觉 痒觉 神经病理性疼痛 中医药 

分 类 号：R285.5[医药卫生—中药学]