中药网络药理学研究中存在的问题与发展展望  

Challenges and prospect in research of Chinese materia medica network pharmacology

作　　者：孟凡翠[1] 汤立达[1,2] MENG Fan-cui;TANG Li-da(Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津药物研究院天津市新药设计与发现重点实验室,天津300301 [2]天津药物研究院,天津300301

出　　处：《中草药》2020年第8期2232-2237,共6页Chinese Traditional and Herbal Drugs

基　　金：天津市新药创制科技重大专项(18ZXXYSY00040)。

摘　　要：网络药理学近年来已成为中药研究的热门工具,其系统性和整体性特点为复杂中药体系的研究提供了新思路,被广泛用于筛选中药有效成分、阐释作用机制和揭示方剂配伍原理等,为中药合理用药提供技术支持,促进中药现代化进展。通过对中药网络药理学研究现状进行梳理分析,指出中药网络药理学研究中存在的问题和面临的挑战,同时对中药网络药理学的发展方向进行了展望。将网络药理学应用于中医药研究时必须要注重中药自身的特点,开发出适合中医药体系研究的网络药理学方法。Network pharmacology has become a hot tool for Chinese materia medica(CMM) research, and its integrity and systematics offer novel ideas for complex CMM system. It is widely used to screen the active component, reveal the action mechanism, and explore the compatibility principle, etc., providing technical support for rational medication of CMM, thus promoting the modernization process of CMM. This paper analyzed the current research status of network pharmacology for CMM. The problems and challenges faced by CMM network pharmacology were pointed out, and its future perspect was also illustrated. When applying network pharmacology to traditional Chinese medicine(TCM), great attentions must be paid to its own characteristics, and new network pharmacology methods suitable for TCM should be developed.

关 键 词：网络药理学 中药 靶点 协同作用 系统性 整体性 

分 类 号：R285[医药卫生—中药学]