基于肠道菌群探讨中药的活性成分及效应物质发现  

Discovery of bioactive compounds and effector substance based on gut microbiota

作　　者：冯五文 乐世俊 刘娟[1] 李芸霞[1] 敖慧[1] 彭成[1] FENG Wu-wen;YUE Shi-jun;LIU Juan;LI Yun-xia;AO Hui;PENG Cheng(Key Laboratory of Characteristic Chinese Medicinal Resources in Southwest,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of TCM Compatibility of Shaanxi Administration of Traditional Chinese Medicine,Shaanxi University of Chinese Medicine,Xi’an 712046,China)

机构地区：[1]成都中医药大学西南特色中药资源重点实验室,四川成都611137 [2]陕西中医药大学陕西省中医药管理局中药配伍重点研究室,陕西西安712046

出　　处：《中草药》2020年第7期1914-1923,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(81891012);国家自然科学基金项目(81630101);国家自然科学基金项目(81503272);国家自然科学基金项目(U19A2010);国家科技重大专项重大新药创制(2108ZX09721001-008);四川省科技厅青年科技创新研究团队(2017TD0001)。

摘　　要：随着现代慢性复杂性疾病发病率的攀升以及中医药在治疗慢性病方面的优势日益凸显,中药的国内外地位与日俱增。而中药活性成分、效应物质及相应作用机制的未知性极大限制了中药的临床接受度与国际化进程。发现直接关切中药药效的活性成分及效应物质是中药研究的关键科学问题之一。在回顾目前中药活性成分发现模式的基础上,跟踪国际研究前沿,结合中药成分特征,依据大多数中药通过口服给药的特点,结合课题组相关研究基础,探讨基于肠道微生态的中药活性成分与效应物质发现研究模式,以期为中药新药研发及作用机制研究等方面提供新思路,助力中药现代化与国际化。With the increase of the chronic complex diseases and the growing advantage of traditional Chinese medicine(TCM)in treating chronic complex diseases,Chinese materia media(CMM)became more and more importance in the world.However,the ambiguity of bioactive compounds,effective materials and their corresponding mechanisms has limited the acceptance of CMM in clinic and the internalization of CMM in the world.As a result,the discovery of bioactive compounds and effective materials that are directly associated with therapeutic effects of CMM is one of the most important scientific question in researching of CMM.Hence,in this article,we briefly reviewed current methods for discovery of bioactive compounds and effective materials.Then,with references related to the international research frontier and the characteristics of CMM ingredients,according to the characteristics of most Chinese medicine through oral administration,combined with the previous research basis of our research group,a research model that is based on gut microbiota was investigated to discover bioactive compounds and effective materials.The aim of this research model is to provide new thoughts on discovery of new drugs,the mechanism study of CMM,etc.,and eventually promote the modernization and internalization of CMM.

关 键 词：活性成分 效应物质 肠道菌群 中药 中医药 中药新药研发 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]