I2/CuO催化的3-乙酰基香豆素和硫脲一锅反应合成3-(2-氨基-4-噻唑基)香豆素衍生物  

I2/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl)Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

作　　者：赵芳 胡洋 李巧 胡胜利 Zhao Fang;Hu Yang;Li Qiao;Hu Shengli(College of Chemistry and Chemical Engineering,Hubei Normal University,Huangshi 435002)

机构地区：[1]湖北师范大学化学化工学院,黄石435002

出　　处：《有机化学》2020年第4期1068-1073,共6页Chinese Journal of Organic Chemistry

基　　金：湖北省高校优秀中青年科技创新团队(No.T201311);湖北省教育厅(No.D20112507)资助项目.

摘　　要：香豆素和噻唑是两类具有广泛的生物活性和药理作用的杂环化合物,合成含噻唑基的香豆素衍生物在药物化学上具有重要的意义.本研究发展了一种方便高效地通过3-乙酰基香豆素和硫脲/N-取代硫脲在I2/CuO催化作用下一锅反应合成3-(2-氨基)-4-噻唑基)香豆素衍生物的方法.所有目标化合物通过核磁共振、红外光谱、质谱分析证实.Coumarin and thiazole are two classes of important heterocycles with many biological activities and pharmacological effects.It is very meaningful to synthesize thiazolyl coumarin derivatives in medicinal chemistry area.In this study,a facile and efficient one-pot process was developed to synthesize substituted aminothiazoles from 3-acetylcoumarins and thiourea/N-substituted thioureas under the media of I2/CuO.All target molecules were characterized by NMR,IR spectra and MS.

关 键 词：香豆素 2-氨基噻唑 一锅反应 I2/CuO 

分 类 号：TQ463[化学工程—制药化工]