口腔微生物群落结构的影响因素  

Factors influencing the structure of the oral microbiome

作　　者：唐灿 刘诗雨[1] 程磊[1] TANG Can;LIU Shiyu;CHENG Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Conservative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Department of Stomatology,Hospital of Chengdu Office of People′s Government of Tibetan Autonomous Region,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,四川成都610041 [2]西藏自治区人民政府驻成都办事处医院口腔科,四川成都610041

出　　处：《口腔疾病防治》2020年第6期390-393,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金面上项目(81870759)。

摘　　要：口腔微生物群落作为人体最多样化的微生物群落之一,其生态失衡不仅可以诱发多种口腔疾病,如龋病、牙髓根尖周病、牙周病等,还与心血管疾病、糖尿病等多种系统性疾病紧密相关。口腔微生物群落结构受多种因素影响,本文就口腔微生物群落结构的影响因素作一综述,文献复习结果表明:环境因素在口腔微生物群落的塑造中起重要作用,而遗传和饮食因素的影响目前尚有争议;此外,系统性疾病也可能影响口腔微生物群落结构。目前,高通量测序研究已确定一些“核心微生物群”,不同环境、不同遗传背景下的“核心微生物群”将是下一步的研究方向。The oral microbiome has been identified as one of the most diverse microbial communities in the human body,and the ecological imbalance of the oral microbiome can not only induce a variety of oral diseases,such as dental caries,pulpitis,apical periodontitis,and periodontal diseases,but also is closely related to cardiovascular diseases,dia⁃betes and other systemic diseases.The structure of the oral microbiome is affected by multiple factors.This paper re⁃views and summarizes the effects of genetics,the environment,diet and systemic diseases.Literature reviews have shown that environmental factors play an important role in the structure of the oral microbiome,while the influence of genetic and dietary factors is still controversial.In addition,systemic diseases may also affect the oral microbial commu⁃nity.High⁃throughput sequencing studies have identified some“core microbiota”,and“core microbiota”in different en⁃vironments and in different genetic backgrounds will be the next research direction.

关 键 词：口腔微生物群落 多样性 核心微生物群 遗传 环境 饮食 龋病 牙髓病 根尖周病 心血管疾病 糖尿病 

分 类 号：R78[医药卫生—口腔医学]