中药酚性化合物对口腔微生物调节作用的研究进展  

Research progress on the regulation of phenolic compounds of traditional Chinese herbs on oral microbes

作　　者：宗雅文 程磊[1] 郭强 周学东[1] 任彪[1] Zong Yawen;Cheng Lei;Guo Qiang;Zhou Xuedong;Ren Biao(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,成都610041

出　　处：《华西口腔医学杂志》2020年第3期319-323,共5页West China Journal of Stomatology

基　　金：国家自然科学基金(81600858)。

摘　　要：酚性化合物广泛存在于天然中药植物中,具有抗氧化、抗炎等药理特性,是许多中药发挥药理作用的主要成分。口腔微生物的组成、代谢等关系着口腔微生态的平衡,是口腔疾病发生、发展的关键因素。近来的研究发现,中药酚性化合物可以调节口腔微生物组成、代谢及致病毒力等,从而在龋病、牙周病、口腔黏膜感染等口腔疾病的防治领域发挥着重要作用。本文就中药酚性化合物对口腔微生物的调节作用作一综述。Phenolic compounds are widely found in natural Chinese medicinal plants and have excellent pharmacological properties,such as antioxidation and anti-inflammation.They are the main pharmacological components of many medicinal Chinese herbs.Oral microbiota,especially its composition and metabolism,is highly related to the balance of oral microecology and plays a key role in the occurrence and development of oral diseases.Recent studies have shown that phenolic compounds of traditional Chinese herbs can prevent and treat oral diseases,such as caries,periodontal disease,and oral mucosal infection,by regulating the composition,metabolites,and virulence of oral microorganisms.This review will summarize and discuss the regulation of phenolic compounds on oral microbes.

关 键 词：中药 酚性化合物 口腔微生物 致病毒力 

分 类 号：R780.2[医药卫生—口腔医学]