National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016  

作　　者：Xuemin Fu Zhenzhou Wan Yanpeng Li Yihong Hu Xia Jin Chiyu Zhang 

机构地区：[1]Pathogen Discovery and Big Data Center,CAS Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]Medical Laboratory of Taizhou Fourth People’s Hospital,Taizhou 225300,China [3]Viral Disease and Vaccine Translational Research Unit,CAS Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Virologica Sinica》2020年第1期21-33,共13页中国病毒学（英文版）

基　　金：supported by the TOTAL foundation,and the Grants from the National Science and Technology Major Project of China(2017ZX10103009-002);the "One Belt One Road" Project(153831KYSB20170043)of the Chinese Academy of Sciences;the133 Project of Institut Pasteur of Shanghai,CAS.

摘　　要：Hand, foot and mouth disease(HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71(EVA71) and coxsackievirus A16(CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and 2015, CVA6 exceeded both EVA71 and CVA16 to become the leading cause of HFMD in some provinces. However, there still lacks a comprehensive overview on the molecular epidemiology and evolution of HFMD-related enteroviruses at the national level. In this study, we performed systematic epidemiological analyses of HFMD-related enteroviruses using the data of 64 published papers that met the inclusion criteria, and conducted phylogenetic analyses based on 12,080 partial VP1 sequences identified in China before 31 st June 2018. We found that EVA71 prevalence has decreased sharply but other enteroviruses have increased rapidly from 2008 to 2016 and that one subtype of each enterovirus is represented during the epidemic. In addition, four genotypes EVA71_C4, CVA16_B1, CVA6_D and CVA10_C are the most predominant enterovirus strains and collectively they cause over 90% of all HFMD cases in China according to the phylogenetic trees using representative partial VP1 sequences. These four major enterovirus genotypes have different geographical distributions, and they may cocirculate with other genotypes and serotypes. These results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD.

关 键 词：ENTEROVIRUS Hand foot and MOUTH disease(HFMD) Molecular EPIDEMIOLOGY Evolution Genotype 

分 类 号：R512.5[医药卫生—内科学] R181.3[医药卫生—临床医学]