噻吗洛尔滴眼液联合卤米松外敷治疗婴幼儿皮肤表浅型血管瘤  

Timolol eye drops combined with Halometasone in the treatment of superficial hemangioma of infant skin

作　　者：赵菊花 庄化迪 王洁 何启敏 杨羽 ZHAO Juhua;ZHUANG Huadi;WANG Jie;HE Qimin;YANG Yu(Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong 637000, Sichuan, China)

机构地区：[1]南充市中心医院·川北医学院第二临床医学院,四川南充637000

出　　处：《西部医学》2020年第5期745-748,共4页Medical Journal of West China

基　　金：四川省卫生和计划生育委员会科研课题(18PJ421)。

摘　　要：目的探讨0.5%马来酸噻吗洛尔滴眼液联合卤米松乳膏局部外用治疗婴幼儿皮肤表浅型血管瘤的临床疗效和安全性。方法选取2018年1月~2019年3月在我院治疗的90例婴幼儿皮肤表浅型血管瘤患儿,随机分为实验组和对照组两组,每组各45例。治疗组先外用卤米松乳膏再外敷0.5%马来酸噻吗洛尔滴眼液;对照组单用0.5%马来酸噻吗洛尔滴眼液外敷。随访治疗3个月。定期观察和详细记录血管瘤大小、颜色变化、质地及用药后的不良反应。结果试验结束时即第12周末,实验组总有效率明显优于对照组,两组疗效比较差异有统计学意义(P=0.006)。实验组起效时间明显早于对照组(P<0.05),从第8周末开始,两组的总有效率有显著性差异(P<0.05)。两组均未见严重的不良反应(P>0.05)。结论0.5%马来酸噻吗洛尔滴眼联合卤米松外敷比单用马来酸噻吗洛尔滴眼起效快、总有效率高,安全性高,简单易行,值得临床借鉴。Objective To investigate the clinical effect and safety of 0.5%timolol maleate eye drops combined with halometasone cream in the treatment of infantile superficial hemangioma of skin.Methods 90 infants with superficial hemangioma of skin treated in January 2018 to March 2019 in our hospital were selected and were randomly divided into the treatment group(45 cases)and the control group(45 cases).The treatment group was externally treated with halometasone cream and then externally applied with 0.5%timolol maleate eye drops.The control group was simply given timolol maleate eye drops.Patients in both groups were treated continuously for 3 months.The size,color,texture and adverse reactions of hemangiomas were observed and recorded in detail.Results At the end of the experiment(the 12th weekend),the total effective rate of the treatment group(88.9%)was significantly better than that of the control group(64.6%),(P=0.006,P<0.01).The effect time of the treatment group was significantly earlier than that of the control group.From the 8th weekend,the total effective rate of the two groups was significantly different.No serious adverse reactions were observed in both groups.Conclusion 0.5%timolol maleate eye drops combined with halometasone cream external application had faster onset and higher total efficiency than simple application of timolol maleate eye drops.It had high safety and it is easy to operate.

关 键 词：皮肤表浅型血管瘤 马来酸噻吗洛尔滴眼液 卤米松乳膏 婴幼儿 

分 类 号：R732.2[医药卫生—肿瘤]