miRNA在白内障形成中的作用  

The role of miRNA in cataract formation

作　　者：陈文静 刘平[1] CHEN Wenjing;LIU Ping(Eye Hospital,the First Affiliated Harbin Medical University,Harbin 150001,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科医院,黑龙江省哈尔滨市150001

出　　处：《眼科新进展》2020年第5期497-500,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助项目(编号81470618);黑龙江省青年科学基金项目(编号QC2013C099),黑龙江省自然科学基金资助项目(编号H2016038);黑龙江省博士后科研启动金资助(编号LBH-Q15102)。

摘　　要：白内障是全球重要的致盲原因之一,其形成与衰老、紫外线照射、外伤等多种因素有关。白内障的治疗和预防是改善致盲率的重点,因此掌握白内障形成的机制非常重要。微小RNA(microRNA,miRNA)是一种影响基因及蛋白表达的非编码RNA。已经发现多种miRNA与白内障有关,其作为新的诊断标记物和治疗靶点具有潜在应用前景。本文对近年miRNA在白内障形成中的作用的研究进展进行综述。Cataract is one of the important causes of blindness in the world,and its occurence is related to aging,ultraviolet radiation,trauma and other factors.The treatment and prevention of cataract is the key to improving the blindness rate,so it is very important to grasp the mechanism of cataract formation.MicroRNA(miRNA)is a non-coding RNA that affects the expression of genes and proteins.A variety of miRNAs have been found to be involved in cataract,and they have potential applications as new diagnostic markers and therapeutic targets.This article reviews the research progress of miRNA in cataract formation in recent years.

关 键 词：微小RNA 白内障 晶状体 晶状体上皮细胞 

分 类 号：R776.1[医药卫生—眼科]