奥美拉唑与泮托拉唑治疗消化道溃疡出血的有效性及对免疫功能的影响  

Efficacy of Omeprazole and Pantoprazole in Treatment of Peptic Ulcer Bleeding and Their Influence on Immune Function

作　　者：张蓓琳[1] 符策月[2] 黄玉伟[1] ZHANG Beilin;FU Ceyue;HUANG Yuwei(Department of Gastroenterology,Shanghai First People′s Hospital Baoshan Branch,Shanghai 200940,China;Department of Infection,Shanghai First People′s Hospital Baoshan Branch,Shanghai 200940,China)

机构地区：[1]上海市第一人民医院宝山分院消化内科,上海200940 [2]上海市第一人民医院宝山分院感染科,上海200940

出　　处：《医学综述》2020年第10期2065-2069,共5页Medical Recapitulate

摘　　要：目的探讨奥美拉唑与泮托拉唑治疗消化道溃疡出血的有效性及对免疫功能的影响。方法选择2016年2月至2018年10月上海市第一人民医院宝山分院收治的91例消化道溃疡出血患者为研究对象,根据治疗方法不同分为对照组(n=45)和观察组(n=46)。对照组采用奥美拉唑针剂治疗,每次40 mg,每日2次,静脉推注;观察组给予泮托拉唑粉针治疗,每次40 mg,每日2次,临用前将本品与0.9%氯化钠注射液100 mL稀释静脉滴注,1 h内滴完。两组均持续治疗1周。对比两组的临床疗效,幽门螺杆菌(Hp)感染根除率,止血时间、疼痛消失时间,治疗前后的免疫功能变化,以及不良反应发生率。结果观察组总有效率高于对照组[95.7%(44/46)比77.8%(35/45)](P<0.05)。观察组Hp根除率高于对照组[95.7%(44/46)比80.0%(36/45)],观察组止血时间、疼痛消失时间短于对照组[(1.42±0.32)d比(2.61±0.52)d,(0.82±0.22)d比(1.51±0.31)d](P<0.01)。治疗后两组CD4+和CD4+/CD8+高于治疗前,观察组高于对照组(P<0.05);CD8+低于治疗前,观察组低于对照组(P<0.05),两组各指标组间、时点间、组间和时点间交互作用差异有统计学意义(P<0.05)。观察组总不良反应发生率低于对照组[4.3%(2/46)比22.2%(10/45)](P<0.05)。结论与奥美拉唑相比,泮托拉唑治疗消化道溃疡出血具有临床疗效显著、安全性高的特点,也可改善患者免疫功能。Objective To investigate the efficacy of omeprazole and pantoprazole in the treatment of gastrointestinal ulcer bleeding and their effect on immune function.Methods A total of 91 patients with gastrointestinal ulcer bleeding admitted to Shanghai First People′s Hospital Baoshan Branch from Feb.2016 to Oct.2018 were included in the study.They were divided into a control group(n=45)and an observation group(n=46)according to the treatment methods.The control group was treated with omeprazole injection,40 mg each time,2 times a day,by intravenous injection;the observation group was given pantoprazole powder injection,40 mg each time,2 times a day,intravenously infused diluted with 100 mL 0.9%sodium chloride injection and finished within 1 hour.Both groups continued treatment for 1 week.The clinical efficacy,Helicobacter pylori(Hp)infection eradication rate,hemostasis time,pain disappearance time,incidence of adverse reactions,immune function changes of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group[95.7%(44/46)vs 77.8%(35/45)](P<0.05).The Hp eradication rate in the observation group was higher than that in the control group[95.7%(44/46)vs 80.0%(36/45)],and the hemostasis time and pain disappearance time in the observation group were shorter than those in the control group[(1.42±0.32)d vs(2.61±0.52)d,(0.82±0.22)d vs(1.51±0.31)d](P<0.01).After treatment,the CD4+and CD4+/CD8+of the two groups were higher than before treatment,and the observation group was higher than the control group(P<0.05);CD8+was lower than before treatment,and the observation group was lower than the control group(P<0.05);there were statistically significant differences in each index between groups,time points,and interactions of groups and time points(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group[4.3%(2/46)vs 22.2%(10/45)](P<0.05).Conclusion Compared with omeprazole treatment,pantoprazole has t

关 键 词：消化道溃疡出血 幽门螺杆菌感染 免疫功能 

分 类 号：R573.2[医药卫生—消化系统]