口腔黏膜病和口腔症状与炎症性肠病的相关性研究  

Study on Association between Oral Mucosal Diseases,Oral Symptoms,and Inflammatory Bowel Disease

作　　者：张丽敏[1] 周家敏 张涵[1] 陆云洋 魏晓渝 张馨方 陈白莉[3] 杨军英[1] ZHANG Limin;ZHOU Jiamin;ZHANG Han;LU Yunyang;WEI Xiaoyu;ZHANG Xinfang;CHEN Baili;YANG Junying(Department of Stomatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China;Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院口腔科,广东广州510080 [2]中山大学附属口腔医院,光华口腔医学院,广东广州510055 [3]中山大学附属第一医院消化内科,广东广州510080

出　　处：《口腔医学研究》2020年第4期387-392,共6页Journal of Oral Science Research

基　　金：2018年国家级大学生创新训练计划项目(编号:201801150)。

摘　　要：目的:研究炎症性肠病(inflammatory bowel disease,IBD)的活动性、病程、用药类型与口腔黏膜病和口腔症状的关系。方法:采用横断面研究对389例IBD患者[265例克罗恩病(CD组)和124例溃疡性结肠炎(UC组)]和265例健康者(对照组)进行问卷调查和口腔黏膜检查。数据分析运用χ2检验和Logistic回归。结果:CD组沟纹舌的患病率比对照组增加(P=0.021),其患病风险增加7.76倍。相比对照组,CD和UC组口干和口腔异味的发生率均明显增加(P<0.05),口干的发生风险分别增加1.98倍和1.48倍,口腔异味的发生风险分别增加0.96倍和0.72倍。活动期CD患者复发性阿弗他溃疡和沟纹舌的患病率比缓解期者增加(P=0.048,P=0.009)。口腔扁平苔藓的患病率随CD病程的延长而增加(P=0.035)。CD组中应用氨基水杨酸制剂者口腔黏膜异常检出率比免疫抑制剂者增加(P=0.003)。结论:IBD患者口腔黏膜病的患病风险和口腔症状的发生风险增加,并与IBD的活动性、病程、用药类型相关,亟需口腔卫生宣教和多学科综合治疗。Objective:To study the association between activity,duration,and drug therapy of inflammatory bowel disease(IBD)and oral mucosal diseases and oral symptoms.Methods:In this cross-sectional study,questionnaires and oral mucosal examinations were conducted among 389 IBD patients[265 with Crohn’s disease(CD)and 124 with ulcerative colitis(UC)]and 265 healthy controls.Chi-square tests and logistic regression were used to analyse the data.Results:The prevalence of fissured tongue in CD patients was higher than controls(P=0.021),and the risk increased by 7.76 times.Compared with controls,CD and UC patients had higher incidence of xerostomia and halitosis(P<0.05),and the risk of xerostomia increased by 1.98 times and 1.48 times,respectively,and the risk of halitosis increased by 0.96 times and 0.72 times,respectively.Active CD had higher prevalence of recurrent aphthous ulcer and fissured tongue compared with that in remission(P=0.048,P=0.009).The prevalence of oral lichen planus increased over the duration of CD patients(P=0.035).The detection rate of abnormal oral mucosa in CD patients treated with aminosalicylate was higher than that in immunosuppressive patients(P=0.003).Conclusion:Patients with IBD have higher risk of oral mucosal diseases and oral symptoms,which are associated with IBD activity,duration,and drug therapy,and require oral health education and multidisciplinary treatment.

关 键 词：口腔黏膜病 口腔症状 炎症性肠病 克罗恩病 溃疡性结肠炎 

分 类 号：R57[医药卫生—消化系统]