血浆纤维蛋白原水平与前列腺癌临床病理特征的关系研究  

Study on the association between plasma fibrinogen level and clinicopathological characteristics of prostate cancer

作　　者：冷区 苏维 李军 王烁 祝炜安 王喻[2] 李传印[1] 李炳坤[1] 温星桥[2] 毛向明 Leng Qu;Su Wei;Li Jun;Wang Shuo;Zhu Weian;Wang Yu;Li Chuanyin;Li Bingkun;Wen Xingqiao;Mao Xiangming(Department of Urology,Zhu Jiang Hospital of Southern Medical University,Guangzhou 510282,China;Department of Urology,the Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China;Guangzhou Panyu Central Hospital,Guangzhou 51400,China)

机构地区：[1]南方医科大学珠江医院泌尿外科,广州510282 [2]中山大学附属第三医院泌尿外科,广州510630 [3]番禺中心医院泌尿外科,广州511400

出　　处：《中华腔镜泌尿外科杂志（电子版）》2020年第1期12-15,共4页Chinese Journal of Endourology(Electronic Edition)

基　　金：国家自然科学基金面上项目(81773277);广州市科技计划项目(201803010014)。

摘　　要：目的分析血浆纤维蛋白原(FIB)与前列腺癌临床病理特征的关系,探讨FIB在前列腺癌患者病情评估中的临床价值。方法回顾性分析从2006年1月至2017年12月间珠江医院456例前列腺癌(PCa)患者及322例前列腺增生(BPH)患者的临床病理资料。分析前列腺癌患者术前血浆纤维蛋白原水平与纤维蛋白原(FIB)、Gleason评分、总前列腺特异抗原(tPSA)值、游离前列腺特异抗原(fPSA)值、游离前列腺特异抗原百分比(f/tPSA)、年龄、体质量指数(BMI)、临床T分期(cT)、有无淋巴结转移、有无骨转移、危险度分级之间的相关性。结果两组患者的术前血浆FIB中位水平分别为3.52(2.97~4.35)g/L、3.12(2.61~3.45)g/L。前列腺癌组显著高于前列腺增生组,差异有统计学意义(P<0.05)。前列腺癌患者术前血浆FIB水平与年龄、tPSA、Gleason评分、c T分期改变呈正相关性(P<0.05)。结论前列腺癌患者术前血浆纤维蛋白原水平与肿瘤病理评分、临床T分期以及相关血清指标有密切关系,可以联合相关影像及实验室检查结果预测患者疾病进展情况及其转归。Objective To analyze the relationship between plasma fibrinogen level and clinicopathological characteristics of prostate cancer.The value of plasma fibrinogen in early progress of prostate cancer was investigated.Methods A retrospective analysis of clinical and pathological data from 456 patients with prostate cancer(PCa)and 322 patients with benign prostatic hyperplasia(BPH)in Zhujiang Hospital who met the study criteria from January 2006 to December 2017 was performed.Age,body mass index(BMI),fibrinogen(FIB),Gleason score,total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),free prostate specific antigen percentage(f/tPSA),clinical T stage(cT),presence or absence of lymph node metastasis,presence or absence of bone metastasis and risk stratification were collected and analyzed.SPSS 19.0 software package was used to analyze the correlation between the fibrinogen and the above indexes.Results The preoperative plasma FIB median in group PCa and BPH were 3.52 g/L(IQR,2.97-4.35)and 3.12 g/L(IQR,2.61-3.45),respectively.The plasma FIB was significantly increased in patients with PCa compared to patients with BPH(P<0.05).The preoperative plasma fibrinogen level was significant positively correlated with age,tPSA,Gleason score,cT stage(P<0.05).Conclusion Preoperative plasma fibrinogen level in patients with prostate cancer was associated with tumor pathological score,clinical T stage and related serum indicators,which can be combined with relevant imaging and laboratory examination results to predict the disease progression and outcome of patients.

关 键 词：前列腺癌 纤维蛋白原 病理特征 疾病进展 

分 类 号：R737.25[医药卫生—肿瘤]