济宁市健康体检人群>50岁男性和绝经后女性骨质疏松及维生素D水平分析  

Vitamin D level and osteoporosis in men over 50years old and postmenopausal women in Jining urban area

作　　者：马晓庆[1] 司广新 王倩[2] MA Xiao-qing;SI Guang-xin;WANG Qian(Jining NO.1 People's Hospital,Jining 272000,P.R.China)

机构地区：[1]济宁市第一人民医院内分泌科,山东济宁272000 [2]济宁市第一人民医院脊柱外科,山东济宁272000

出　　处：《社区医学杂志》2020年第1期20-23,共4页Journal Of Community Medicine

基　　金：山东省医药卫生科技发展计划(2017WS864)。

摘　　要：目的维生素D为一种重要的微量营养素,它主要参与了钙磷及骨代谢,而维生素D缺乏是很多慢性疾病的危险因素。骨质疏松为一种增龄相关的骨骼疾病,随着我国老龄化日趋严重,骨质疏松已成为重要公共健康问题。本研究旨在了解济宁城市地区>50岁男性及绝经后女性维生素D营养状况及骨质疏松患病情况。方法收集2016-10-01-2018-09-30济宁市第一人民医院查体中心的健康人群查体资料,女212名,已为绝经,年龄<70岁;男286名,年龄50~70岁。以上人群均在济宁城市地区居住>10年,进行病史采集。采用Cobas 8000全自动生化分析仪检测上述人群空腹血糖、血清钙、血清磷、血清镁及甲状旁腺激素;采用液相串联质谱法测定上述人群中血清25-羟维生素D〔25-(OH)D〕水平;采用双能X线骨密度仪测量上述人群非优势侧挠骨远端1/3骨密度。结果济宁城市地区>50岁男性维生素D充足率及缺乏率分别为14.34%和50.70%;绝经后女性维生素D充足率及缺乏率分别为9.91%和60.38%;>50岁男性血清25-(OH)D平均值为(21.34±7.12)ng/mL,高于绝经后女性的(19.87±6.31)ng/mL,t=9.465,P=0.008。济宁城市地区>50岁男性骨量减少及骨质疏松检出率分别为41.26%和9.09%,绝经后女性分别为43.40%和38.68%;两组人群骨质疏松检出率相比,差异有统计学意义,χ2=67.76,P<0.001。结论济宁城市地区>50岁男性及绝经后女性人群血清25-(OH)D水平低,维生素D缺乏率高,骨质疏松患病率高。OBJECTIVE Vitamin D is an essential micronutrient that plays a key role in calcium and phosphorus homeostasis and bone metabolism.In addition,vitamin D deficiency has also been associated with an increased risk of many chronic diseases.Osteoporosis is an age-related bone disease.With the aging of our country becoming more and more serious,osteoporosis has become an important public health problem in our country.This study aims to investigate the nutritional status of vitamin D and the prevalence of osteoporosis in men over 50years old and postmenopausal women in Jining urban area.METHODS The data from October 1,2016to September 30,2018of health examination center in Jining First People's Hospital were collected.The age of women was less than 70years old after menopause,and the age of men was 50-70years old,with residential history of local urban areas over 10years.Medical history of aboval population was collected.Fasting blood glucose,serum calcium,serum phosphorus,serum magnesium and parathyroid hormone were measured by Cobas 8000automatic biochemical analyzer.Serum 25-hydroxyvitamin D[25-(OH)D]level was determined by liquid chromatography tandem mass spectrometry(LC-MS),and bone mineral density(BMD)of the distal third of non-dominant lateral flexion was measured by dual-energy X-ray absorptiometry(DEX-ray).RESULTS The vitamin D adequacy and deficiency rates of men over 50years old in Jining urban area were 14.34%and 50.70%,respectively,and those of postmenopausal women were 9.91%and 60.38%,respectively.The average 25-(OH)D of males over 50years old was(21.34±7.12)ng/ml,which was significantly higher than that of postmenopausal females[(19.87±6.31)ng/ml],t=9.465,P=0.008.The detection rate of osteopenia and osteoporosis in males over 50years old was 41.26%and 9.09%,respectively.The detection rate of osteopenia and osteoporosis in postmenopausal women was 43.40%and 38.68%,respectively.The detection rare of osteoporosis in males over 50years old was significantly lower than that in postmenopausal females(χ2=67.

关 键 词：25-羟维生素D 维生素D缺乏 骨质疏松症 50岁以上男性 绝经后女性 济宁市 

分 类 号：R153[医药卫生—营养与食品卫生学]