辅助生殖技术子代安全性及对策思考  

Research advance in the risk of offspring with assisted reproductive technology and strategies to improve the safety of maternity and progeny

作　　者：贺木兰[1] 孙晓溪[1] He Mulan;Sun Xiaoxi(Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中华生殖与避孕杂志》2019年第10期838-843,共6页Chinese Journal of Reproduction and Contraception

摘　　要：随着不孕症发病率的增加和辅助生殖技术(assisted reproductive technology,ART)的发展,通过ART出生的人群在社会总人口中占比不断增大,ART所涉及的非生理性干预是否会对子代的安全造成隐患,这一问题逐渐引起生殖领域研究者们的关注。虽然多数研究报道对ART安全性持乐观态度,但也不乏一些令人担忧的研究结果。本文从围产儿结局、出生缺陷、内分泌代谢疾病、体格认知发育异常和儿童期肿瘤方面,综述近几年的研究结果,思考如何提高ART母体及子代的安全性。With the increase in the incidence of infertility and the development of assisted reproductive technology(ART),the proportion of people born through ART in the total population of the society is increasing.It causes wide attention whether or not the non-physiological interventions involved in ART would threaten the safety of the offspring.Although most studies suggest that ART is safety,there are some worrying findings.This article reviews the results of perinatal outcomes,birth defects,endocrine and metabolic diseases,physical and cognitive abnormalities and childhood tumors,and considers how to improve the safety of maternity and progeny.

关 键 词：生殖技术 辅助 先天畸形 内分泌系统疾病 认知障碍 

分 类 号：R714.8[医药卫生—妇产科学]