β型人乳头瘤病毒致皮肤鳞状细胞癌机制的研究进展  

Research progress on the mechanism ofβhuman papillomavirus induced cutaneous squamous cell carcinoma

作　　者：马庆宇 梁俊琴[2] Ma Qingyu;Liang Junqin(Graduate College of Xinjiang Medical University,Urumqi 830054,China;Department of Dermatology,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830000,China)

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830054 [2]新疆维吾尔自治区人民医院皮肤科,乌鲁木齐830000

出　　处：《国际肿瘤学杂志》2019年第12期760-763,共4页Journal of International Oncology

基　　金：国家自然科学基金(81760494)。

摘　　要：人乳头瘤病毒(HPV)感染鳞状上皮,可诱发过度增生性病变,β型人乳头瘤病毒(β-HPV)是HPV根据L1蛋白核酸序列的不同分型中常见的一种.近年来皮肤鳞状细胞癌(CSCC)发病率增加,β-HPV可能参与了CSCC的发病,通过病毒E6和E7蛋白分别抑制p53和pRb抑癌基因,在癌症的起始环节起重要作用.因此,β-HPV是预防CSCC的靶点,特别是对于接受器官移植后免疫抑制的患者.Human papillomaviruse(HPV)infects squamous epithelium and induces hyperproliferative lesions.βhuman papillomavirus(β-HPV)is a common type of HPV according to the nucleic acid sequence of L1 protein.In recent years,the incidence of cutaneous squamous cell carcinoma(CSCC)has increased,β-HPV may be involved in the pathogenesis of CSCC.Besides,β-HPV inhibits p53 and pRb tumor suppressor genes through virus E6 and E7 proteins,which plays an important role in the initial stage of cancer.Therefore,theβ-HPV is a target for preventing CSCC,especially for patients with immunosuppression who have received organ transplantation.

关 键 词：肿瘤 鳞状细胞 β乳头状瘤病毒属 机制 

分 类 号：R73[医药卫生—肿瘤]