工作记忆在重性抑郁症患者社会功能损害中的中介作用  

Mediating effect of working memory in the impairment of social function in patients with depressive disorder

作　　者：吕浩 丰雷 王刚 Lyu Hao;Feng Lei;Wang Gang(China Clinical Research Center for Mental Disorders, Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心,100088

出　　处：《神经疾病与精神卫生》2019年第12期1063-1068,共6页Journal of Neuroscience and Mental Health

基　　金：国家重点研发计划(2016YFC1307200);国家科技重大专项重大新药创制(2018ZX09734005);北京市医院管理局“青苗”计划专项(QML20181904)。

摘　　要：目的探讨抑郁症患者工作记忆对社会功能影响的中介作用.方法本研究为横断面观察研究,连续纳入北京安定医院2017年6月至2018年8月符合美国精神障碍诊断与统计手册第Ⅳ版(DSM-Ⅳ)诊断标准的抑郁症患者149例,采用患者健康问卷(PHQ-9)、席汉残疾量表(SDS)、自定顺序指示任务(SOPT,包括总点击次数)分别评估其抑郁严重程度、社会功能和工作记忆,利用层次回归模型检验工作记忆在抑郁严重程度和社会功能之间的中介作用.结果(1)PHQ-9总分与SDS总分呈正相关(r=0.41,P<0.01),与SOPT总点击次数呈正相关(r=0.19,P<0.05),SDS总分与SOPT总点击次数呈正相关(r=0.16,P<0.05).(2)层次回归模型结果及bootstrap结果显示,SOPT总点击次数在PHQ-9总分与SDS总分存在部分的中介作用,中介效应占比为4.09%.结论抑郁症患者的社会功能的确受到工作记忆的中介作用影响,但只是部分的中介效应.Objectives To investigate the mediating effect of working memory on social function in patients with depressive disorder.Methods This study is a cross-sectional study.A total of 149 depressive disorder patients who met the DSM-IV diagnostic criteria were included in Beijing Anding Hospital from June 2017 to Augest 2018.The Patient Health Questionnaire(PHQ-9),Sheehan Disability Scale(SDS),and Self-ordered Pointing Task(SOPT)were applied to evaluate patients'depression severity and social function.Hierarchical regression model was used to test the mediating effect of working memory between depression severity and social function.Results(1)The PHQ-9 total score was positively correlated with the SDS total score(r=0.41,P<0.01),with the click numbers of SOPT(r=0.19,P<0.05),and the SDS total score was positively correlated with the click numbers of SOPT(r=0.16,P<0.05).(2)The results of hierarchical regression model and bootstrap showed that the total number of SOPT clicks had partial mediating effect on the total score of PHQ-9 and SDS,and the proportion of mediating effect was 4.09%.Conclusions The social function of patients with depressive disorder is indeed affected by the mediating effect of working memory,but it is only a partial mediating effect.

关 键 词：抑郁症 工作记忆 社会功能 中介作用 

分 类 号：R74[医药卫生—神经病学与精神病学]