Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease  

作　　者：Song-Sen Su Yan-Fang Lin Hong Zhou 

机构地区：[1]Department of Rheumatology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou,Fujian 362000,China [2]Department of Pharmacy,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou,Fujian 362000,China

出　　处：《Chinese Medical Journal》2020年第8期1002-1004,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from the Natural Science Foundation of Fujian Province,China(No.2017J01351);the Fujian Medical University Sailing Fund,China(No.2016QH086)。

摘　　要：To the Editor:Rheumatic diseases are disorders characterized by joint inflammation,but other organs are also affected.[1]Rheumatic diseases are common in China,and the clinical application of azathioprine(AZA),a purine analog immunosuppressant,for these diseases is attracting increasing attention.Although AZA is widely used in the treatment of rheumatic diseases,its clinical application is limited by adverse effects,especially leukopenia.

关 键 词：URINE DISEASES ORGANS 

分 类 号：R593.2[医药卫生—内科学]