TRAIL及其受体在食管癌中表达的研究  

Study on the expression of TRAIL and its receptors in esophageal squamous cell cancer

作　　者：车娜 柴建原 韩丽红[2] 金培彧[2] 贾彦彬 武金宝[2] 党彤[2] CHE Na;CHAI Jianyuan;HAN Lihong;JIN Peiyu;JIA Yanbin;WU Jinbao;DANG Tong(Graduate School of Baotou Medical College, Baotou 014040, China;Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College;School of Nursing, Baotou Medical College)

机构地区：[1]内蒙古科技大学包头医学院研究生学院,内蒙包头014040 [2]内蒙古科技大学包头医学院第二附属医院消化科 [3]内蒙古科技大学包头医学院护理学院

出　　处：《包头医学院学报》2020年第1期40-42,共3页Journal of Baotou Medical College

基　　金：国家自然基金(81960445,81550020);内蒙古自治区自然科学基金(2018LH08081);包头市科技计划(2016X1030-11-01,2019Z3011-04,2019P3080,2019P3078);包头医学院科学研究基金(BYJJ-DF201704,BYJJ-DF201604,BYJJ-YF201626)。

摘　　要：目的:研究食管癌及癌旁组织中肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor related apoptosis inducing ligand,TRAIL)及其死亡受体(death receptor,DR)和诱骗受体(decoy receptor,DCR)的表达。方法:应用免疫组化法检测食管癌及其癌旁组织中TRAIL、DR和DCR的表达。结果:免疫组化染色显示,癌组织TRAIL、死亡受体DR4、死亡受体DR5、诱骗受体DCR1和诱骗受体DCR2均有表达,而癌旁正常组织均为阴性。结论:TRAIL及其受体在食管癌组织中均有表达,癌旁正常组织均无表达,食管癌的发生、发展可能与TRAIL及其受体的表达相关,本研究为食管鳞癌发生机制的研究及TRAIL抗性的研究提供帮助。Objective:To investigate the expression of tumor necrosis factor-related apoptosis ligand(TRAIL),death receptor(DR)and decoy receptor(DCR)in esophageal squamous cell carcinoma and its adjacent tissues.Methods:Immunohistochemistry was used to detect the expression of TRAIL,DR and DCR in esophageal squamous cell cancer and its adjacent tissues.Results:Immunohistochemical staining showed that TRAIL,DR4,DR5,DCR1 and DCR2 were expressed in the cancer tissues,while normal adjacent tissues were negative.Conclusion:TRAIL and its receptors were expressed in esophageal cancer tissues,but not in adjacent normal tissues.The occurrence and development of esophageal cancer might be related to the expression of TRAIL and its receptors.This study provides help for the study of the pathogenesis of esophageal squamous cell carcinoma and TRAIL resistance.

关 键 词：食管鳞癌 肿瘤坏死因子相关凋亡诱导配体 死亡受体 诱骗受体 

分 类 号：R73[医药卫生—肿瘤]