GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia  

作　　者：Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li 

机构地区：[1]Mental Health Center and Psychiatric Laboratory,State Key Laboratory of Biotherapy,West China Hospital of Sichuan University,Chengdu 610041,China [2]West China Brain Research Center,West China Hospital of Sichuan University,Chengdu 610041,China [3]Department of Biomedical Engineering,Pennsylvania State University,University Park,PA 16802,USA [4]Analytic and Translational Genetics Unit,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USA [5]Broad Institute of MIT and Harvard,Cambridge,MA 02141,USA

出　　处：《Neuroscience Bulletin》2020年第2期97-109,共13页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81630030,81130024,and 81528008);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme(81461168029);the National Basic Research Development Program of China(2016YFC0904300);the Science and Technology Project of the Health Planning Committee of Sichuan(19PJ090);the National Natural Science Foundation of China for Distinguished Young Scholars(81501159).

摘　　要：The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia.

关 键 词：ERBB4 SCHIZOPHRENIA MRI Gene pathway Mouse 

分 类 号：R749.3[医药卫生—神经病学与精神病学]