拉莫三嗪联合丙戊酸钠治疗脑卒中后继发癫痫患者的临床观察  

Clinical observation of lamotrigine combined with sodium valproate in the treatment of epilepsy following stroke

作　　者：单伟 SHAN Wei(The First Department of Neurology,Central Hospital Affiliated to Shenyang Medical College,Shenyang110024,China)

机构地区：[1]沈阳医学院附属中心医院神经内一科,辽宁沈阳110024

出　　处：《中国现代医生》2020年第10期126-128,共3页China Modern Doctor

摘　　要：目的对于脑卒中后继发癫痫患者临床治疗时选择拉莫三嗪联合丙戊酸钠用药的效果进行研究。方法选取我院在2017年6月~2018年6月间收治的90例脑卒中继发癫痫患者作为本研究对象,采用随机法分为观察组与对照组,每组45例。对照组患者单纯采用丙戊酸钠治疗,而观察组患者在对照组药物基础上联合拉莫三嗪进行治疗,对比两组患者的治疗1年后的治疗总有效率、治疗1年后癫痫发作频率和癫痫持续发作时间以及不良反应发生率。结果治疗1年后,观察组治疗的总有效率高于对照组,差异有统计学意义(P<0.05);治疗1年后观察组患者的的癫痫发作频率和癫痫持续发作时间均显著低于对照组,差异有统计学意义(P<0.05);两组不良反应率比较,差异无统计学意义(P>0.05)。结论相比传统采用丙戊酸钠治疗脑卒中后继发癫痫的效果,联合采用拉莫三嗪的临床疗效更加显著,不仅能提高治疗有效率,还能更好的控制癫痫发作频率和持续发作时间,改善患者的生活状态,值得在临床推广应用。Objective To study the effect of lamotrigine combined with sodium valproate in the treatment of epilepsy following stroke.Methods 90 patients with epilepsy following stroke who were admitted in our hospital from June 2017 to June 2018 were selected as the study subjects.They were randomly divided into the observation group and the control group,with 45 cases in each group.The control group was treated with sodium valproate alone,while the observation group was treated with lamotrigine on the basis of the control group.After one year after treatment,the total effective rate,the attack frequency and duration of epileptic seizures and the incidence of adverse reactions were compared between the two groups.Results After one year of treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);the attack frequency and duration of epilepsy in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05);there was no statistical difference in adverse reactions between the two groups(P>0.05).Conclusion Compared with the traditional use of sodium valproate alone in the treatment of epilepsy after stroke,the combined use of lamotrigine has a more significant clinical effect.It can not only improve the treatment effect,but also control the frequency and duration of epileptic seizures,improve the living quality of patients,which is worth promoting in the clinical treatment of such diseases.

关 键 词：拉莫三嗪 丙戊酸钠 脑卒中 继发癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]