链霉蛋白酶+西甲硅油+碳酸氢钠溶液配制后放置不同时间口服对胃镜检查质量的影响  

Effect of oral administration of pronase+simethicone+sodium bicarbonate solution on the quality of gastroscopy

作　　者：刘之枫 谈涛 顿珊珊 吴娟 李蜀豫 Zhi-feng Liu;Tao Tan;Shan-shan Dun;Juan Wu;Shu-yu Li(Department of Gastroenterology,the Third People’s Hospital of Hubei Province,Jianghan University,Wuhan,Hubei 430033,China)

机构地区：[1]江汉大学附属湖北省第三人民医院消化内科,湖北武汉430033

出　　处：《中国内镜杂志》2020年第5期26-31,共6页China Journal of Endoscopy

摘　　要：目的探讨链霉蛋白酶+西甲硅油+碳酸氢钠溶液配制后放置不同时间口服对胃镜检查质量的影响。方法选取该院2018年11月-2019年4月行无痛胃镜的患者1200例,随机分为4组,A组(n=300):链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后立即口服;B组(n=300):链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置1 h口服;C组(n=300):链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置2 h口服;D组(n=300):链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置3 h口服。4组患者均口服混合液60 mL,20 min后行无痛胃镜检查,对比分析4组患者胃镜视野清晰度及微小病灶发现率。结果A组和B组胃镜视野清晰度及病灶发现率比较,差异无统计学意义(P>0.05);A组和B组胃镜视野清晰度及病灶发现率明显优于C组和D组(P<0.05);C组和D组胃镜视野清晰度均较差,病灶发现率较低,两组比较,差异无统计学意义(P>0.05)。结论链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置1 h内口服效果最佳,可以明显改善胃镜视野及提高微小病灶发现率,溶液放置2 h后口服,胃镜视野清晰度明显变差,微小病灶发现率明显降低。Objective To investigate the effect of oral administration of pronase+simethicone+sodium bicarbonate solution on the quality of gastroscopy.Methods 1200 patients with painless gastroscopy from November 2018 to April 2019 were randomly divided into 4 groups.Group A(n=300):oral administration of pronase+simethicone+sodium bicarbonate solution;Group B(n=300):pronase+simethicone+sodium bicarbonate solution was placed and placed for 1 hour orally;Group C(n=300):pronase+simethicone+sodium bicarbonate solution and placed for 2 hours orally;Group D(n=300):pronase+simethicone+sodium bicarbonate solution was placed and placed orally for 3 hours.All the 4 groups of patients were given 60 ml of oral mixture,and painless gastroscopy was performed 20 minutes after oral administration.The visual field clarity and microscopic lesion discovery rate of the 4 groups were compared.Results There was no significant difference in the depth of visual field and the rate of lesions between the patients in group A and group B(P>0.05).The patients in group A and group B were significantly better than those in group C and D(P<0.05);patients in group C and group D had poor visual field vision and low incidence of lesions.There was no significant difference between the two groups(P>0.05).Conclusions After pronase+simethicone+sodium bicarbonate solution,the best oral effect after 1 hour of placement can significantly improve the microscopic field of view to improve the discovery rate of microscopic lesions.After the solution is placed for 2 hours,the visual field clarity is obviously worse,and the rate of lesion discovery was significantly reduced.

关 键 词：胃镜检查 链霉蛋白酶 西甲硅油 放置时间 胃镜视野 

分 类 号：R573[医药卫生—消化系统]