3-异丁基戊二酸的合成工艺改进  

An Improved Process of Pregabalin

作　　者：尤海烽 王菲 张乔乔 祁秀秀[1] 陈文华[1] You Haifeng;Wang Fei;Zhang Qiaoqiao;Qi Xiuxiu;Chen Wenhua(Dept.of Chemical and Pharmaceutical Engineering,Changzhou Vocation College of Engineering and Technology,Changzhou 213164,China)

机构地区：[1]常州工程职业技术学院化工与制药工程系,江苏常州213164

出　　处：《广东化工》2020年第10期52-52,共1页Guangdong Chemical Industry

基　　金：江苏省青蓝工程项目(2018);江苏省产学研合作项目(BY2019155);江苏省“双创计划”科技副总项目(FZ20190353)。

摘　　要：以丙二酸和异戊醛为原料经过缩合、脱羧得到5-甲基-2-己烯酸乙酯,再经过迈克尔加成、脱羧、水解得到3-异丁基戊二酸,该合成工艺总收率为89%。该法收率高、操作简便、易于工业化生产。3-isobutylglutaric acid was obtained with an overall yield of 89 %, from malonic acid and isovaleraldehyde via condensation, decarboxylation to give 3-isobutylglutaric acid, which was subjected to Michael addition, decarboxylation and hydrolysis. The synthesis is simple, easily controlled and high yield for the industrial production.

关 键 词：丙二酸 异戊醛 3-异丁基戊二酸 普瑞巴林 

分 类 号：O625.63[理学—有机化学]