长春西汀联合人参总皂甙治疗后循环脑梗死临床研究  

Clinical effect of vinpocetine combined with ginsenoside on cerebral infarction of posterior circulation

作　　者：李洪杰 冯青春 王冬梅[2] 曾冬阳[3] LI Hongjie;FENG Qingchun;WANG Dongmei(Department of Emergency,Haikou Third People’s Hospital,Haikou 571100)

机构地区：[1]海口市第三人民医院,海口571100 [2]南方医科大学南方医院神经内科,广州510515 [3]海南医学院基础教研室,海口571199

出　　处：《陕西中医》2020年第5期612-614,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：海南省自然科学基金资助项目(817133)。

摘　　要：目的:探讨长春西汀联合人参总皂甙对后循环脑梗死患者的疗效及对脑血流灌注、脑梗死体积、血管狭窄程度的影响。方法:选择后循环脑梗死患者80例,随机分为对照组和观察组,各40例。对照组采用脑梗死基础性对症治疗。观察组在对照组治疗基础上给予长春西汀联合人参总皂甙治疗。比较两组患者治疗前后脑血流灌注(Qmean、Vmax、Vmin、RI)、脑梗死体积、中医证候积分、血管狭窄程度、NIHSS评分及预后情况。结果:治疗后,两组Qmean、Vmax、Vmin均升高,RI均降低;观察组治疗后Qmean、Vmax、Vmin均高于对照组,RI低于对照组(P<0.05)。治疗后,两组脑梗死体积均升高,中医证候积分、血管狭窄程度、NIHSS评分均降低,但观察组脑梗死体积、血管狭窄程度、NIHSS评分均低于对照组(P<0.05)。观察组预后良好率85.00%高于对照组65.00%(P<0.05)。结论:长春西汀联合人参总皂甙可显著改善后循环脑梗死患者脑血流灌注状态、降低脑梗死体积、缓解脑水肿,改善血管狭窄程度,临床治疗效果满意。Objective:To investigate the effect of vinpocetine combined with ginsenoside on cerebral blood flow perfusion,cerebral infarction volume and vascular stenosis in patients with posterior circulation cerebral infarction.Methods:80 patients with posterior circulation cerebral infarction were randomly divided into control group and observation group,40 cases in each group.The control group was treated with basic symptomatic treatment of cerebral infarction.The observation group was treated with vinpocetine and ginsenoside on the basis of the control group.Cerebral blood perfusion(qmean,Vmax,Vmin,RI),cerebral infarction volume,TCM syndrome score,degree of vascular stenosis,NIHSS score and prognosis were compared before and after treatment.Results:After treatment,qmean,Vmax and Vmin were increased and RI was decreased in the two groups;after treatment,qmean,Vmax and Vmin in the observation group were higher than those in the control group and RI was lower than that in the control group(P<0.05).After treatment,the volume of cerebral infarction in the two groups increased,the TCM syndrome score,the degree of vascular stenosis and NIHSS score decreased,but the volume of cerebral infarction,the degree of vascular stenosis and NIHSS score in the observation group were lower than those in the control group(P<0.05).The good prognosis rate of the observation group was 85.00% higher than that of the control group(P<0.05).Conclusion:Vinpocetine combined with ginsenoside can significantly improve the cerebral blood flow perfusion state,reduce the volume of cerebral infarction,relieve cerebral edema,improve the degree of vascular stenosis in patients with posterior circulation cerebral infarction.The clinical effect is satisfactory,and it can be applied and popularized.

关 键 词：长春西汀 人参总皂甙 后循环脑梗死 脑血流灌注 脑梗死体积 血管狭窄程度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]