首发精神分裂症和抑郁症患者视空间工作记忆研究  

A study on visuo-spatial working memory in patients with first-episode depressive disorder and schizophrenia

作　　者：孔文婷 陈学丛 朱国辉[1] KONG Wenting;CHEN Xuecong;ZHU Guohui(Weifang Mental Health Center,Weifang 262400,China)

机构地区：[1]潍坊市精神卫生中心,山东潍坊262400 [2]潍坊市人民医院

出　　处：《精神医学杂志》2019年第5期361-364,共4页Journal of Psychiatry

摘　　要：目的研究首发精神分裂症、抑郁症患者的视空间工作记忆特点。方法选取精神分裂症患者(精神分裂症组)42例,精神分裂症Ⅰ级亲属(精神分裂症亲属组)50名,抑郁症患者(抑郁症组)35例,抑郁症Ⅰ级亲属(抑郁症亲属组)45名及健康对照者(对照组)30名。采用可重复成套神经心理状态测验(RBANS)、视空间工作记忆测试(SWM)、经典n-back工作记忆模型对视空间工作记忆能力进行评估。结果精神分裂症组和抑郁症组RBANS总分及各因子分和矩阵工作记忆的0-back、2-back均低于对照组(P<0.01),SWM中工作记忆反应时较对照组长,正确数较对照组少(P<0.01);精神分裂症组RBANS总分及各因子分和矩阵工作记忆的0-back、2-back低于抑郁症组(P<0.05),SWM中工作记忆反应时较抑郁症组长,正确数较抑郁症组少(P<0.05)。精神分裂症亲属组和抑郁症亲属组RBANS总分及各因子分、矩阵工作记忆的0-back、2-back试验评分均低于对照组,SWM中工作记忆反应时较对照组长,正确数较对照组少(P<0.05)。精神分裂症亲属组矩阵工作记忆的2-back评分高于精神分裂症组(P<0.01)。结论精神分裂症、抑郁症患者确实存在视空间工作记忆的损伤,且前者更加严重。两种疾病的I级亲属同样存在不同程度的视空间工作记忆损伤,且这种损伤具有遗传特质性,可能先于疾病本身出现,不会随着疾病的缓解而好转。Objective To explore the characteristics of visuo-spatial working memory in patients with first-episode schizophrenia and depressive disorder.Methods 42 patients with first-episode schizophrenia(schizophrenia group),50 first-degree relatives of schizophrenia(schizophrenia relative group),35 patients with first-episode depression(depression group),45 first-degree relatives of depression(depression relative group)and 30 healthy controls(control group)were selected and assessed with Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Spatial Working Memory(SWM)and classic N-back working memory models.Results In schizophrenia group and depression group,the total score and all factor scores of RBANS as well as N-back test scores were significantly lower than those in control group(P<0.01),and the working memory response time of SWM were longer than that in control group,and the correct numbers were less than that in control group(P<0.01).In schizophrenia group,the total score and all factor scores of RBANS as well as N-back test scores were significantly lower than those in depression group(P<0.05),and the working memory response time of SWM was longer than that in depression group,and the correct number was less than that in depression group(P<0.05).In schizophrenia relative group and depression relative group,the total score and all factor scores of RBANS as well as N-back test scores were significantly lower than those in control group,and the working memory response time of SWM were longer than that in control group,and the correct numbers were less than that in control group(P<0.05).The 2-back score in schizophrenia relative group was higher than that in schizophrenia group(P<0.01).Conclusion Patients with schizophrenia and depression do have impaired visuo-spatial working memory,and the former is more serious.The first-degree relatives of these two disorders also have visual spatial working memory impairment in different degree,and this kind of injury has genetic traits,which may appear bef

关 键 词：首发 精神分裂症 抑郁症 Ⅰ级亲属 视空间工作记忆 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]