东莞市虎门镇5484例宫颈癌筛查患者HPV感染现状与宫颈病变的关系  

The Relationship between HPV Infection and Cervical Lesions in 5 484 Cervical Cancer Screening Patients in Humen Town, Dongguan City

作　　者：王碧霞[1] 黄春优[1] 李少云 孟海燕[1] 黄爱群 陈颖茵 WANG Bixia;HUANG Chunyou;LI Shaoyun;MENG Haiyan;HUANG Aiqun;CHEN Yingyin(Humen Hospital of Dongguan City,Dongguan 523900,China;不详)

机构地区：[1]广东省东莞市虎门医院,广东东莞523900

出　　处：《中国医学创新》2020年第11期73-77,共5页Medical Innovation of China

基　　金：2019年东莞市社会科技发展(一般)项目(201950715020708)。

摘　　要：目的:研究东莞市虎门镇5 484例宫颈癌筛查患者HPV感染现状,并探讨患者HPV感染与宫颈病变的关系。方法:选取2016年1月-2019年12月在本院门诊就诊、同时行液基薄层细胞学(TCT)检查和HPV分型检测进行宫颈癌筛查的5 484例女性患者,对TCT和/或HPV结果呈阳性的患者行阴道镜检查,并在阴道镜对可疑病变部位取活检,进行病理学诊断。统计5 484例宫颈癌筛查患者中HPV阳性感染率及其不同亚型,比较不同年龄段HPV感染情况及不同亚型HPV感染在宫颈病变中的分布。结果:5 484例宫颈癌筛查患者中HPV感染率为30.18%。年龄≤25岁和>65岁HPV感染率较高,分别为35.43%和37.25%,36~45岁感染率较低,为27.09%。不同年龄段HPV感染率比较,差异有统计学意义(P<0.05)。13种高危亚型中HPV52、HPV58、HPV16的感染率较高,分别为23.02%、15.26%、13.85%。5种低危亚型中HPV4和HPV6的感染率较高,分别为6.63%、3.45%。HPV52、HPV58、HPV16、其他10种HPV、低危型HPV高级别病变发生率比较,差异有统计学意义(P<0.05)。高危亚型HPV宫颈高级别病变发生率较高,其中HPV16亚型高级别病变发生率最高。结论:宫颈癌筛查患者中各年龄段的HPV感染率不同,≤25岁和>65岁HPV感染率较高,高危型HPV感染率较高,患者高危型HPV感染与宫颈病变密切相关,通过筛查地区患者高危型HPV感染情况,监测HPV感染高危人群可以减少人群宫颈病变的发病率。Objective:To study the status of HPV infection in 5 484 cervical cancer screening patients in Humen town,Dongguan city,and to explore the relationship between HPV infection and cervical lesions.Method:A total of5 484 female patients who visited the outpatient department of our hospital from January 2016 to December 2019 and underwent TCT (liquid-based thin-layer cytology) examination and HPV typing test for cervical cancer screening were selected.Patients with positive TCT and/or HPV results were examined by colposcopy,and biopsy of suspicious lesions was performed by colposcopy for pathological diagnosis.A total of 5 484 cervical cancer screening patients with HPV positive infection rates and different subtypes,HPV infection in different age groups and the distribution of different subtypes of HPV infection in cervical lesions were compared.Result:HPV infection rate was 30.18% in 5 484 cervical cancer screening patients.The infection rate of HPV were higher when the age was ≤25 years old and >65 years old,35.43% and 37.25% respectively.The infection rate of 36-45 years old was low,it is 27.09%.Comparison of HPV infection rates in different age groups,the differences were statistically significant (P<0.05).The infection rates of HPV52,HPV58 and HPV16 were higher among the 13 high risk subtypes,23.02%,15.26% and 13.85% respectively.The infection rates of HPV4 and HPV6 were higher among the five low-risk subtypes,they were 6.63% and 3.45% respectively.The incidence of high-grade lesions of HPV52,HPV58,HPV16,other 10 types of HPV and low-risk HPV was compared,the difference was statistically significant (P<0.05).The high-risk subtype of HPV has a high incidence of cervical high-grade lesions,of which HPV16 has the highest incidence.Conclusion:The incidence rate of HPV infection in different ages of cervical cancer screening patients is different,≤25 years old and >65 years old have a higher rate of HPV infection,a higher rate of high-risk HPV infection.The high-risk HPV infection is closely related to the cervic

关 键 词：宫颈癌筛查 HPV 感染 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]