富亮氨酸α2糖蛋白1在胰腺癌组织中的表达及临床意义  

Expression and clinical significance of leucine-rich-alpha-2-glycoprotein 1 in pancreatic cancer tissue

作　　者：朱陈[1] 卞兆连[1] 仇松 曹亮[1] ZHU Chen;BIAN Zhaolian;QIU Song;CAO Liang(Department of Gastroenterology,the Third Peoples′Hospital of Nantong,Jiangsu Province,Nantong 226006)

机构地区：[1]江苏省南通市第三人民医院消化内科,南通226006

出　　处：《南通大学学报（医学版）》2020年第2期151-153,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市卫健委青年医学人才科研基金项目(WQ2016010)。

摘　　要：目的:检测富亮氨酸α2糖蛋白1(leucine-rich-alpha-2-glycoprotein 1,LRG1)在胰腺癌组织及癌旁组织中的表达情况,研究LRG1表达情况与胰腺癌的发生、发展、侵袭、转移之间的关系。方法:选取2010年1月1日—2017年12月31日南通市第三人民医院外科手术后病理确诊为胰腺癌的患者40例,采用免疫组化检测癌组织及癌旁组织的LRG1表达概况,并分析LRG1的表达与胰腺癌临床特征的关系。结果:胰腺癌组织中LRG1的高表达率明显高于癌旁组织(72.5%vs 20.0%,χ^2=20.113,P<0.001)。胰腺癌组织LRG1的表达与患者肿瘤分期、分化程度及有无淋巴结转移相关(χ^2=6.771、7.064、4.409,均P<0.05);与性别、年龄、肿瘤部位无相关性(均P>0.05)。结论:LRG1可能在胰腺癌的发展侵袭转移中起一定的作用,有可能作为评估胰腺癌预后的分子指标和治疗靶点。Objective:To detect the expression of leucine-richα2 glycoprotein 1(LRG1)in pancreatic cancer tissues and adjacent tissues,and to study the relationship between LRG1 expression and the occurrence,development,invasion and metastasis of pancreatic cancer.Methods:From January 1,2010 to December 31,2017,40 patients with pancreatic cancer confirmed pathologically by surgery in Nantong Third People′s Hospital were selected,cancerous tissues and adjacent tissues were collected,the expression level was detected by immunohistochemistry,and the relationship between LRG1 expression and clinical characteristics of pancreatic cancer was analyzed.Results:The expression rate of LRG1 in pancreatic cancer tissues was significantly higher than that in adjacent tissues(72.5%vs 20.0%,χ^2=20.113,P<0.001).The expression of LRG1 in pancreatic cancer tissue is correlated with tumor stage,differentiation degree and presence or absence of lymph node metastasis(χ^2=6.771,7.064 and 4.409,P<0.05).There was no correlation with sex,age and tumor location(P>0.05).Conclusion:LRG1 may play a certain role in the development,invasion and metastasis of pancreatic cancer,and may be used as a molecular indicator and therapeutic target for evaluating the prognosis of pancreatic cancer.

关 键 词：胰腺癌 富亮氨酸α2糖蛋白1 免疫组织化学 临床特征 

分 类 号：R735.9[医药卫生—肿瘤]