辐射剂量对基于深度学习的计算机辅助诊断系统肺结节测量准确性的影响  

Impact of radiation dose on the measurement accuracy of nodule volume and long diameter using deep learning-based computer aided diagnostic system

作　　者：贾永军 于楠[1,2] 贺太平 段海峰[1,2] 杨创勃 张喜荣[1,2] 潘宁 于勇[1,2] JIA Yongjun;YU Nan;HE Taiping;DUAN Haifeng;YANG Chuangbo;ZHANG Xirong;PAN Ning;YU Yong(Department of Medical Imaging of Affiliated Hospital of Shaanxi Chinese Medicine University,Shaanxi Chinese Medicine University,Xianyang 712000,China)

机构地区：[1]陕西中医药大学附属医院医学影像科,陕西咸阳712000 [2]陕西中医药大学,陕西咸阳712000 [3]北京推想科技有限公司,北京100025

出　　处：《中国中西医结合影像学杂志》2020年第3期224-226,231,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(81701691);陕西省自然科学基金面上项目(2019JM-361);陕西中医药大学创新团队基金项目(2019-YS04)。

摘　　要：目的:通过胸部仿真体模实验,分析不同辐射剂量对基于深度学习的计算机辅助诊断系统(DL-CAD)测量肺结节长径及三维容积准确性的影响。方法:使用MSCT扫描含有8个不同直径(5、8、10、12 mm)和密度(实性、磨玻璃)的球形肺结节的成年男性仿真胸部体模。扫描参数:120 kV,噪声指数14,通过调整前置自适应统计迭代重建技术(pre-ASIR-V)的权重比例(0、40%、80%、100%)调整管电流。采用0、40%、80%比例的混合迭代算法(ASIR-V)重建12组薄层CT图像。应用DL-CAD测量体模内各个结节的长径和三维容积,比较不同辐射剂量条件下肺结节长径、三维容积测量的绝对百分误差(APEd、APEv)。采用单因素方差分析及LSD-t检验比较0、40%、80%、100%pre-ASIR-V扫描条件的APEd和APEv。结果:4次CT扫描的有效辐射剂量分别为9.68、3.78、0.82、0.23 mSv。随辐射剂量降低,肺结节的APEd和APEv逐渐增大(F=4.906,P=0.003;F=5.612,P=0.001),100%pre-ASIR-V的APEd和APEv显著大于其他扫描条件(均P<0.05),其余各辐射剂量条件下两两比较差异均无统计学意义(均P>0.05)。结论:DL-CAD测量肺结节长径及三维容积的准确性与辐射剂量相关,低辐射剂量可显著降低测量准确性。Objective:To investigate the impact of radiation dose on the measurement accuracy of nodule volume and long diameter with a deep learning-based computer aided diagnostic system(DL-CAD)using an anthropomorphic chest phantom.Methods:An anthropomorphic chest phantom consisting of realistic pulmonary vessels was used to simulate chest CT imaging.The chest phantom contains 8 spherical lung nodules of different diameters(5,8,10,12 mm)and densities(solid and ground glass nodules)and were scanned on a 256-slice CT with the following parameters:120 kVp,noise index of 14,pre-ASIR-V was adjusted to 0%,40%,80%and 100%to modulate the tube current.Images were reconstructed with 1.25 mm using lung kernel and 0%,40%,80%pre-ASIR-V.Absolute percentage error(APE)of the diameter(APEd)and volume(APEv)of the lung nodules was used to describe the accuracy of measurement.One-way ANOVA and LSD-t test were used to compare APEd and APEv of nodules with different radiation doses.Results:Effective radiation dose of different scans with 0%,40%,80%,100%pre-ASIR-V were 9.68,3.78,0.82 and 0.23 mSv,respectively.For both APEd and APEv,0%,40%,80%,100%pre-ASIR-V scans increased significantly as the effective dose decreased.And there were significant differences of APEd and APEv between 100%pre-ASIR-V and other radiation doses(both P<0.05),while there were no statistical differences between the two radiation doses each other of the condition of 0%,40%and 80%pre-ASIR-V(all P>0.05).Conclusion:The radiation dose can impact the measurement accuracy of nodule volume and long diameter with DL-CAD.

关 键 词：辐射剂量 肺结节 深度学习 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]