Acsl4在浸润性乳腺癌组织中的表达及其临床意义  

The expression of Acsl4 in invasive breast carcinoma tissues and its clinical significance

作　　者：刘永娟 李小静 刘秀萍 杨珂 舒维清 王长一 Liu Yongjuan;Li Xiaojing;Liu Xiuping;Yang Ke;Shu Weiqing;Wang Changyi(Department of Pathology,Shanghai Fifth People's Hospital,Fudan University,Shanghai 200240,China;Department of Pathology and Pathophysiology,Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属上海市第五人民医院病理科,上海200240 [2]复旦大学基础医学院病理与病理生理学系,上海200032

出　　处：《现代肿瘤医学》2020年第12期2050-2053,共4页Journal of Modern Oncology

基　　金：复旦大学附属上海市第五人民医院院级医学重点专科(编号:2017WYZDZK08)。

摘　　要：目的:探讨Acsl4在浸润性乳腺癌组织中的表达及其临床意义。方法:采用免疫组织化学法检测108例浸润性乳腺癌组织中Acsl4的表达。结果:108例浸润性乳腺癌组织中,33例(30.6%)阳性表达,75例(69.4%)阴性表达。组织学G3级的乳腺癌组织中Acsl4阳性率为42.3%(22/52),高于G1+G2级的阳性率(19.6%,11/56),差异具有统计学意义(P<0.05)。ER阳性组织的Acsl4的阳性率15.8%(6/38),低于ER阴性的病例(38.6%,27/70),差异具有统计学意义(P<0.05)。Acsl4的表达与患者年龄、肿瘤大小、淋巴结是否转移、HER2、PR、p53、Ki67的表达情况无统计学意义的相关性(P均>0.05)。结论:Acsl4在浸润性乳腺癌组织中存在异常表达,其阳性表达与乳腺癌患者组织学分级较高及ER阴性表达密切相关。Objective:To examine the expression and the clinical significance of Acsl4 in invasive breast carcinoma.Methods:The protein expression of Acsl4 in paraffin-embedded samples from 108 patients with invasive breast carcinoma was detected by immunohistochemical staining.Results:Of all 108 cases examined,33 cases had positive and 75 cases had negative expression of Acsl4.The positive expression rate of Acsl4 protein was 42.3%(22/52)in the cases of histological grade G3,which was significantly higher than those in cases of grade G1+G2(19.6%,11/56)(P<0.05).The positive expression rate of Acsl4 protein was 15.8%(6/38)in ER-positive cases,which was significantly lower than those in ER-negative cases(38.6%)(P<0.05).The positive expression of Acsl4 was not related to the patients’age,tumor size,lymph node metastasis,expression of HER2,PR,p53,and Ki67(P>0.05).Conclusion:Acsl4 is abnormally expressed in invasive breast carcinoma,and its positive expression is closely related to higher histological grade and negative ER expression.

关 键 词：浸润性乳腺癌 长链脂酰辅酶A合成酶4 雌激素受体 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]