p16、Ki67及FRα预测低度宫颈上皮内瘤变转归的研究进展  

The research progress of the predictive effect of p16,Ki67 and FRαon the evolution of low grade cervical intraepithelial neoplasia

作　　者：马希 郝敏[2] Ma Xi;Hao Min(Shanxi Medical University,Shanxi Taiyuan 030000,China;The Second Hospital of Shanxi Medical University,Shanxi Taiyuan 030000,China)

机构地区：[1]山西医科大学,山西太原030000 [2]山西医科大学第二医院,山西太原030000

出　　处：《现代肿瘤医学》2020年第12期2168-2172,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81972452);国家卫计委公益性行业科研专项(编号:201402010);山西省重点研发计划项目(编号:201803D31121);山西省卫计委科研课题(编号:2018GW04)。

摘　　要：宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)已发现与宫颈癌密切相关,根据异常程度分3级CIN(CIN1,CIN2和CIN3)。约60%的CIN1可自然消退,仅有少部分发生进展。目前,迫切需要一些生物标志物作为预测因子来预测病变的转归。经检索国内外文献发现,目前大部分研究结果发现生物标志物p16、Ki67的染色结果对于CIN1的预后有预测意义,并且有部分学者研究了p16/Ki67双染结果也可以很好的预测,而目前仅少数人研究了FRα在预测CIN1转归时的意义,认为FRα可能有一定预测价值。关于这些生物标志物的预测价值,还需要其他大型的、长时间的临床随访来进一步研究它们的准确性和可靠性,也需要进行更加深入的研究去发现其他更为精准的标志物。Cervical intraepithelial neoplasia(CIN)has been found to be closely related to cervical cancer,which can be classified into three grades of CIN(CIN1,CIN2,and CIN3)according to the degree of abnormality.About 60%of CIN1 naturally subsides,with only a small part progressing.At present,some biomarkers are urgently needed as predictors to predict the outcome of lesions.After searching for domestic and foreign literature,most of the current research results show that the staining results of biomarkers p16 and Ki67 have predictive value for the prognosis of CIN1.Some scholars have found that the p16/Ki67 double staining results also have a good predictive effect.At present,very few people have studied the significance of FRαin predicting the outcome of CIN1,and they believe that FRαmay have a certain predictive value.Regarding the predictive value of these biomarkers,we believe that other large,long-term clinical follow-ups are needed to further study their accuracy and reliability,as well as more in-depth research to find other more accurate markers.

关 键 词：低度宫颈上皮内瘤变 宫颈癌 免疫组织化学染色 生物标志物 P16 KI67 FRα 

分 类 号：R737.33[医药卫生—肿瘤]