调强放疗时代诱导化疗在Ⅱ~Ⅳa期鼻咽癌中的研究进展  

Research Progress of Induction Chemotherapy for StageⅡ~Ⅳa Nasopharyngeal Carcinoma in the Era of Intensity-modulated Radiotherapy

作　　者：张煜婕 陈杰[1,3] 陈涵波 狄文忆 古亮 何侠 尹丽[1,2] ZHANG Yu-jie;CHEN Jie;CHEN Han-bo;DI Wen-yi;GU Liang;HE Xia;YIN Li(The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research,Nanjing 210009,China;The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing 210000,China;Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]南京医科大学附属肿瘤医院&江苏省肿瘤医院&江苏省肿瘤防治研究所,江苏南京210009 [2]南京医科大学第四临床医学院,江苏南京210000 [3]徐州医科大学,江苏徐州221000

出　　处：《肿瘤学杂志》2020年第4期289-294,共6页Journal of Chinese Oncology

基　　金：国家自然科学基金(81672989);医院科研基金重点项目(ZK201602);院优才计划,院青年专业技术人才培养经费(2017YYCJH-02);中国博士后科学基金(2018M632266);博士后科研经费(SZL201705)。

摘　　要：调强放射治疗的应用使得鼻咽癌的生存得到显著改善,但Ⅱ~Ⅳa期鼻咽癌治疗失败的主要原因仍为远处转移。诱导化疗由于具有减轻肿瘤负荷、消除微转移等优势在临床得到广泛关注,但诱导化疗在Ⅱ期鼻咽癌中的应用价值以及在局部晚期鼻咽癌中的最佳治疗模式尚不明确,全文回顾分析近年来诱导化疗联合调强放疗的相关研究,就调强放疗时代诱导化疗在Ⅱ~Ⅳa期鼻咽癌中相关进展作一综述。The application of intensity-modulated radiotherapy(IMRT)has significantly improved the survival of nasopharyngeal carcinoma(NPC)patients,but distant metastasis remains the main treatment failure mode for stageⅡ~Ⅳa NPC.Induction chemotherapy has been widely used in clinical practice due to its advantages of reducing tumor burden and eliminating micro-metastasis.However,the value of induction chemotherapy in stageⅡNPC and the optimal treatment mode of induction chemotherapy in locally advanced NPC are still unclear.This article reviews the progress of induction chemotherapy for stageⅡ~Ⅳa NPA in the era of intensity-modulated radiotherapy.

关 键 词：鼻咽肿瘤 调强放疗 诱导化疗 Ⅱ~Ⅳa期 

分 类 号：R739.63[医药卫生—肿瘤]