原发性乳腺鳞状细胞癌临床病理分析  

Clinicopathologic Analysis of Primary Squamous Cell Carcinoma of the Breast

作　　者：陈宇[1] 陈智伟[2] 陈仲辉 李金秋 周君 林伟[1,3] CHEN YU;CHEN Zhiwei;CHEN Zhonghui;LI Jinqiu;ZHOU Jun;LIN Wei(Department of Breast Surgery,The Affiliated Hospital of Putian University,Putian Fujian 351100,China;Department of Pathology,The Affiliated Hospital of Putian University,Putian Fujian 351100,China;Department of Clinical Medicine,Fujian Medical University,Fuzhou Fujian 350004,China)

机构地区：[1]莆田学院附属医院乳腺外科,福建莆田351100 [2]莆田学院附属医院病理科,福建莆田351100 [3]福建医科大学临床医学部,福建福州350004

出　　处：《莆田学院学报》2020年第2期66-70,共5页Journal of putian University

基　　金：莆田市科技计划项目(2019S3001)。

摘　　要：探讨原发性乳腺鳞状细胞癌(PSCCB)的临床、病理、超声及预后情况。回顾性收集莆田学院附属医院(我院)2009—2020年9例PSCCB患者的临床、病理、超声和预后资料,并分析相关的文献。结果,PSCCB占我院同期乳腺癌的0.35%,平均直径3.4 cm,6例为囊实性混合回声,病理7例ER、PR、HER2均为阴性;9例P63、CK5/6、E-cad均为阳性,8例P120胞膜、EGFR阳性,中位Ki-67为60%,淋巴结转移率19.8%,平均复发时间25.7月,复发率57.1%。结果表明,PSCCB发病率低,直径较大,超声多为囊实性回声,病理上三阴性多见,P63、CK5/6是诊断的敏感指标,P120和E-cad有助于证明其起源于导管上皮,腋窝淋巴转移率较低,复发时间短,复发率高。The clinical,pathological features,ultrasound diagnosis and prognosis of primary squamous cell carcinoma of breast(PSCCB)were investigated.The clinical,pathological datas,ultrasound diagnosis and prognosis of 9 PSCCB patients admitted in our hospital from 2009 to 2020 were retrospectively collected,and the relevant literature was analyzed.PSCCB accounted for 0.35%of breast cancer in our hospital in the same period,and the average diameter of tumors were 3.4 cm.6 cases presented mixed echo of cystic and solid by ultrasound.7 cases of pathology were negative for ER,PR,HER2.All the 9 cases were detected positive for P63,CK5/6 and E-cad.8 cases were positive for P120 membrane and EGFR.The median ki-67 was 60%,the lymph node metastasis rate was 19.8%,the median recurrence time was 25.7 months,and the recurrence rate was 57.1%.The incidence of PSCCB is low,the tumor diameter is large,the ultrasound is mostly cystic echo,and the pathological triple negative is most common.P63 and CK5/6 are more sensitive indicators in diagnosis.P120 and E-cad may help to indicate its origin form ductal epithelium,the axillary lymph node metastasis rate are relatively low,and high EGFR may be related to shorter recurrence time and higher recurrence rate.

关 键 词：乳腺鳞状细胞癌 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]