The inhibitory activities of Urtica fissa to BPH  

荨麻抑制前列腺增生药理作用研究

作　　者：Jing Huang Lingxin Yang Ning Yang Bowen Yuan Hao Zhang Mengyue Wang 黄晋;杨玲馨;杨宁;袁博文;张浩;王梦月(上海交通大学药学院,上海200240)

机构地区：[1]School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2020年第4期236-243,共8页中国药学（英文版）

基　　金：National Natural Science Fund of China(Grant No.81374067);Shanghai Municipal Health Commission(Grant No.2018ZY002);College Students’Innovation Project(Grant No.IPP20216).

摘　　要：In the present study, the BPH inhibitory activities of Urtica fissa were systematically investigated. Firstly, inhibitory activities of 5α reductase of the alcoholic extracts from different parts(root, stem, leaf, flower and fruit) were evaluated. The results indicated that the root possessed the most significant action. Subsequently, U. fissa root(UFR) was subjected to further pharmacological evaluation using the benign prostate hyperplasia(BPH) model rats induced by testosterone propionate. The results revealed that UFR could significantly decrease the prostate index, alter the hyperplasia tissue morphology, suppress the prostatic growth factors of VEGF, EGF, bF GF and KGF, decrease the inflammation factor levels of TNF-α, IL-1β and IL-6, improve the activities of GSH-Px, CAT and SOD and decrease the MDA level in the prostate of the model rats. Moreover, UFR also significantly suppressed the hormone levels of testosterone and dihydrotestosterone. These results indicated that the possible BPH inhibitory mechanisms of UFR were growth factor suppression, hormone level modulation, anti-inflammation, and anti-oxidative stress.首次对荨麻抗良性前列腺增生作用进行了较系统研究。首先,比较了荨麻不同部位(根、茎、叶、花、果实)对5α-还原酶的抑制作用,发现荨麻根的作用最显著。进而,采用前列腺增生模型大鼠,考察了荨麻根的体内抑制前列腺增生作用。实验发现:荨麻根能显著降低前列腺指数、改变增生组织的病理学形态;抑制前列腺组织中VEGF、EGF、bF GF、KGF等生长因子,降低TNF-α、IL-1β、IL-6等炎症因子水平;提高前列腺组织中GSH-Px、CAT、SOD的活性,降低前列腺组织中MDA的含量。此外,还能降低血清中酸性磷酸酶的活性,以及二氢睾酮、睾酮的水平。结果表明,荨麻具有良好的抑制前列腺增生作用,其作用机理与生长因子抑制、激素调节、抗炎、抗氧化应激等相关。

关 键 词：Urtica fissa root BPH 5Α-REDUCTASE Growth factor suppression Anti-inflammation activity Anti-oxidative stress Hormone level modulation 

分 类 号：R284[医药卫生—中药学]