5Α-REDUCTASE

作品数：16被引量：21H指数：3
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相关领域：医药卫生更多>>
相关作者：李义罗克明吕立堂邓伟孙洁更多>>
相关机构：重庆大学西南大学康涅狄格大学贵州大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Pharmacology & Pharmacy》《Asian pacific Journal of Reproduction》《生殖医学杂志》更多>>
相关基金：国家自然科学基金更多>>
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N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats:Focus on oxidative and sex hormone receptors mechanisms
《Asian pacific Journal of Reproduction》2024年第5期228-240,共13页Victor Oghenekparobo Emojevwe Mega Obukohwo Oyovwi Kayode Ezekiel Adewole Peggy Ejiro Ohwin Adeniran Oluwadamilare Akinola Alexander Obidike Naiho Eze Kingsley Nwangwa Victor Omo-Idonije Motunrayo Lade-Ige Benneth Ben-Azu 
Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechan...
关键词：Di-2-ethylhexyl phthalate TESTOSTERONE Androgen receptor 5Α-REDUCTASE OESTROGEN Luteinizing hormone 
Genotype-phenotype correlations,surgical selections,and postoperative complications of 5α-reductase 2 deficiency in 69 children with hypospadias
《Asian Journal of Andrology》2023年第6期731-736,共6页Xu Wen Li-Jun Fan Wei-Ping Zhang Xin Ni Chun-Xiu Gong 
The study was supported by the Foundation of the Paediatric Medical Coordinated Development Center of Beijing Hospitals Authority(XTYB201808);Jin Lei Paediatric Endocrinology Growth Research Fund for Young Physicians(PEGRF;No.PEGRF202011034);Beijing Municipal Science and Technology Commission(No.Z201100005520061).
5α-reductase 2 deficiency prevents testosterone from being converted to dihydrotestosterone,which causes abnormal urogenital sinus development.The aim of this study was to analyze the relationship between genotype–p...
关键词：5α-reductase 2 deficiency disorders of sex development HYPOSPADIAS 
Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway
《BIOCELL》2023年第6期1389-1396,共8页ZICHEN SHAO CHUNG-YI CHEN XUZHOU CHEN HANWU CHEN MENGQIAO SU HUI SUN YIDAN LI BINGHUA TU ZITONG WANG CHI-MING LIU 
Yichun University Local Development Research Center(Grant No.DF2019002);the PhD Research Foundation of Yichun University(Grant No.211-3360118006);the Animal Care and Ethics Committee of Yichun University(Approval No.2022026).
Background:Benign prostatic hyperplasia(BPH)is a common condition in middle-aged and elderly men.Enlargement of the prostate causes lower urinary tract symptoms.Capsaicin is a phytochemical extracted from chili pepper...
关键词：BPH Apoptosis AUTOPHAGY CAPSAICIN Chili pepper 5Α-REDUCTASE 
The extract of Celtis choseniana Nakai alleviates testosterone-in-duced benign prostatic hyperplasia through inhibiting 5αreductase type 2 and the Akt/NF-κB/AR pathway被引量：1
《Chinese Journal of Natural Medicines》2022年第7期518-526,共9页HONG Geum-Lan KIM Tae-Won LEE Hui-Ju KIM Yae-Ji KIM Kyung-Hyun JUNG Ju-Young 
supported by Chungnam Nation-al University.
Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged prostate.Celtis choseniana Nakai(C.choseniana)is medicinally used to alleviate pain,gastric disease,and lung abscess.In this stu...
关键词：Apoptosis Androgen receptor Benign prostate hyperplasia Celtis choseniana Nakai 5α-Reductase type 2 NF-κB 
Exploring the efficacy of testosterone undecanoate in male children with 5α-reductase deficiency被引量：5
《Pediatric Investigation》2021年第4期249-254,共6页Ying Liu Lijun Fan Xiaoling Wang Chunxiu Gong 
Beijing Municipal Science&Technology Commission(No.Z201100005520061);Jinlei Pediatric Endocrinology Growth Research Fund for Young Physicians(PEGRF)(No.PEGRF201809006)。
Importance:Children with 5-alpha-reductase deficiency(5α-RD)and hypospadias present with micropenis,which makes it difficult to obtain sufficient tissue for urethral reconstruction.Objective:We investigated the thera...
关键词：5α-reductase deficiency MICROPENIS Testosterone undecanoate Treatment PENILE 
The inhibitory activities of Urtica fissa to BPH被引量：1
《Journal of Chinese Pharmaceutical Sciences》2020年第4期236-243,共8页Jing Huang Lingxin Yang Ning Yang Bowen Yuan Hao Zhang Mengyue Wang 
National Natural Science Fund of China(Grant No.81374067);Shanghai Municipal Health Commission(Grant No.2018ZY002);College Students’Innovation Project(Grant No.IPP20216).
In the present study, the BPH inhibitory activities of Urtica fissa were systematically investigated. Firstly, inhibitory activities of 5α reductase of the alcoholic extracts from different parts(root, stem, leaf, fl...
关键词：Urtica fissa root BPH 5Α-REDUCTASE Growth factor suppression Anti-inflammation activity Anti-oxidative stress Hormone level modulation 
Identification of three novel SRD5A2 mutations in Chinese patients with 5α-reductase 2 deficiency被引量：4
《Asian Journal of Andrology》2019年第6期577-581,共5页Tong Cheng Hao Wang Bing Han Hui Zhu Hai-Jun Yao Shuang-Xia Zhao Wen-Jiao Zhu Hua-Ling Zhai Fu-Guo Chen Huai-Dong Song Kai-Xiang Cheng Yang Liu Jie Qiao 
This study is supported by grants from the National Natural Science Foundation(No.81570753,81430019 and 81873652);the Shanghai Jiao Tong University Medical and Engineering Intersection Foundation(No.YG2015QN03).
In this study,we investigated the genetics,clinical features,and therapeutic approach of 14 patients with 5a-reductase deficiency in China.Genotyping analysis was performed by direct sequencing of PCR products of the ...
关键词：5a-reductase type 2 DEFICIENCY DIHYDROTESTOSTERONE MUTATION SRD5A2 
Uromedic^(■) Pumpkin Seed Derived Δ7-Sterols, Extract and Oil Inhibit 5α-Reductases and Bind to Androgen Receptor in Vitro
《Pharmacology & Pharmacy》2018年第6期193-207,共15页Stefan Heim Stephanie Seibt Heike Stier Margret I More 
Omega Pharma Manufacturing GmbH & Co. KG
Dihydrotestosterone (DHT) is implicated in the development of benign prostate hyperplasia (BPH). We investigated if Uromedic? pumpkin (variety of Cucurbita pepo L. convar. citrullinina GREB. var. styriaca GREB) seed s...
关键词：5-Alpha-Reductases 5α-R1 and 5α-R2 Androgen Receptor DIHYDROTESTOSTERONE Uromedic? Pumpkin Seed Oil and Soft Extract (Delta-7) Δ7-Sterols 
Genetic sequencing of a patient with Kallmann syndrome plus 5α-reductase type 2 deficiency
《Asian Journal of Andrology》2017年第3期386-387,共2页Wen Ji Lu-Yao Zhang Fu-Cheng Li Yu Wang Wei He Qi-Qi Yin Zhi-Hong Liao 
Dear Editor, Kallmann syndrome （KS） is a phenotypically and genetically heterogeneous disorder featured by hypogonadotropic hypogonadism and congenital hyposmia or anosmia, accompanined with renal dysplasia, hearin...
Molecular diagnosis of 5α-reductase-2 gene mutation in two Indian families with male pseudohermaphroditism被引量：1
《Asian Journal of Andrology》2008年第5期815-818,共4页Marumudi Eunice Pascal Philibert Bindu Kulshreshtha Francoise Audran Francoise Paris Madan L. Khurana Praveen E. Pulikkanath Kiran Kucheria Charles Sultan Ariachery C. Ammin 
Aim： To identify the genotype of two Indians with male pseudohermaphroditism. Methods： Standard radioimmunoassay procedure was used for estimating hormonal levels. Conventional cytogenetic analysis was carded out fo...
关键词：male pseudohermaphroditism 5αRD-2 deficiency DIHYDROTESTOSTERONE SRD5A2 gene mutation perineoscrotal hypospadias 
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