Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechan...
the National Natural Science Foundation of China(no.82372621).
Unopposed oestrogen is recognised as an inducer of endometrial cancer.Over the past 50 years,the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological onco...
This work was supported by the National Natural Science Foundation of China(81830036,82220108012,82071307 and 82271362);Natural Science Foundation of Jiangsu Province(BK20211552);Gusu Health Personnel Training Project(GSWS2020022 and GSWS2019030).
Background Sex differences affect the occurrence,progression and regression of subarachnoid haemorrhage(SAH).Oestrogen plays a protective role in alleviating the vasospasm and neuronal apoptosis induced by SAH.However...
Case 1: In 1990, a 23-year-old woman, married for two years, with primary infertility, was brought by her husband, with ultrasonography of abdomen, pelvis report stating multiple tiny cysts in both ov...
Trauma and related sequelae result in disturbance of homeostatic mechanisms frequently leading to cellular dysfunction and ultimately organ and system failure. Regardless of the type and severity of injury, gender dim...
AIM To evaluate sex differences and the effects of oestrogen administration in rat gastric mucosal defence.METHODS Sex differences in gastric mucus thickness and accumulation rate, absolute gastric mucosal blood flow ...
Published reports have revealed increased risk of colorectal cancers in people exposed to chlorinated drinking water or chemical derivatives of chlorination. Oestrogen plays a dual positive functions for diminishing t...
We cloned the three androgen response elements(AREs, including AREI, AREII, and AREIII ) with a core transactivation TATA element of the prostate-specific antigen(PSA) promoter into pGL2 basic vector to create an ...
ACKNOWLEDGMENTS This work was supported by a grant from the National Natural Science Foundation of China (No. 30672109).
It is well known that prostate cancer (PCa) occurs predominantly in the peripheral zone (PZ), whereas benign prostatic hyperplasia (BPH) typically develops in the transition zone. To identify possible mechanisms...
The irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the (TTTA)n polymorphism in the aromatase gene (CYP19) ...