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Efficacy and Safety of Erzhu Jiedu Decoction Granules in Treating Mid-advanced Hepatitis B Virus-Associated Primary Liver Cancer Patients with Pi(Spleen)-Deficiency and Dampness-Heat Syndrome
《Chinese Journal of Integrative Medicine》2025年第5期394-401,共8页CHENG Yang WANG Hao-yi WAN Cheng-yi SHI Jie-wen JIN Yuan-yuan HE Sheng-li YIN Bao-bing CHEN Jian-jie 
Supported by Shanghai Municipal Science and Technology Commission Foundation(No.21Y11922800);National Natural Science Foundation of China(No.82374189)。
Objective:To assess the efficacy and safety of Erzhu Jiedu Decoction(EZJDD)Granules in treating mid-advanced hepatitis B virus-associated primary liver cancer(HBV-PLC)patients with Pi(Spleen)-deficiency and dampness-h...
关键词：Erzhu Jiedu Decoction Granules hepatitis B virus-associated primary liver cancer Pi(Spleen)-deficiency and dampness-heat syndrome 
Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development
《Asian Journal of Andrology》2025年第2期211-218,共8页Yu Mao Jian-Mei Huang Yu-Wei Chen-Zhang He Lin Yu-Huan Zhang Ji-Yang Jiang Xue-Mei Wu Ling Liao Yun-Man Tang Ji-Yun Yang 
supported by the Sichuan Science and Technology Program(No.2022JDZH0029 to JYY);the Special Fund for Clinical Research and Translational Medicine from Chinese Academy of Medical Sciences(No.2022-I2M-C&T-B-117 to JYY);the Sichuan Key Research and Development Project from the Department of Science and Technology of Sichuan Province(No.2022YFS0237 to YMT).
This study was conducted retrospectively on a cohort of 68 patients with steroid 5α-reductase 2(SRD5A2)deficiency and 46,XY disorders of sex development(DSD).Whole-exon sequencing revealed 28 variants of SRD5A2,and f...
关键词：ambiguous genitalia disorders of sex development micro-penis sex determination SRD5A2 deficiency 
SLFN11 Deficiency-Induced Gemcitabine Resistance Is Overcome by Agents Targeting the DNA Damage Response in Pancreatic Cancer Cells
《BIOCELL》2025年第4期681-700,共20页Jae Hyeong Kim Yuna Youn Jin-Hyeok Hwang 
supported by the 8th AstraZeneca-KHIDI(Korea Health Industry Development Institute)oncology research program;a research grant was supported by AstraZeneca and by Grant No.02-2022-0020 from the Seoul National University Hospital(SNUBH)Research Fund.
Objectives:SLFN11(Schlafen-11)enhances sensitivity to DNA-damaging agents(DDAs)and DNA damage response(DDR)inhibitors in various cancer types.However,its function in pancreatic cancer(PC)remains largely unknown.This r...
关键词：SLFN11 DNA-damaging agents DNA damage response pancreatic cancer 
Efficacy and Safety of Yangxue Qingnao Pills Combined with Amlodipine in Treatment of Hypertensive Patients with Blood Deficiency and Gan-Yang Hyperactivity:A Multicenter,Randomized Controlled Trial
《Chinese Journal of Integrative Medicine》2025年第3期195-205,共11页WANG Fan GAO Hai-qing LYU Zhe WANG Xiao-ming HAN Hui WANG Yong-xia LU Feng DONG Bo PU Jun LIU Feng ZU Xiu-guang LIU Hong-bin YANG Li ZHANG Shao-ying YAN Yong-mei WANG Xiao-li CHEN Jin-han LIU Min YANG Yun-mei LI Xiao-ying 
Supported by the Geriatric Medicine Development Fund of the China Health Promotion Foundation(No.2020-SRXY-045)。
Objective:To evaluate the clinical efficacy and safety of Yangxue Qingnao Pills(YXQNP)combined with amlodipine in treating patients with grade 1 hypertension.Methods:This is a multicenter,randomized,double-blind,and p...
关键词：hypertension with blood deficiency and Gan-yang hyperactivity Yangxue Qingnao Pills blood pressure variability Chinese medicine syndrome score 
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis
《Science China(Life Sciences)》2025年第3期722-733,共12页Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lv Qian Ren Fei Liu Song Chen Fengxia Ma Tao Cheng Hui Cheng 
supported by the National Key Research and Development Program of China(2020YFE0203000,2021YFA1100900);the National Natural Science Foundation of China(92368202,82270120);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019,2022-I2M-2-001);the CAMS Fundamental Research Funds for Central Research Institutes(3332021093).
Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation,which is crucial for maintaining homeostasis.Acute infections can prompt a hematopoietic response kn...
关键词：fungal infection emergency myelopoiesis FHL2 
Red tinted contact lenses on Ishihara test error scores in color deficient subjects:a pilot study
《International Journal of Ophthalmology(English edition)》2025年第3期462-468,共7页Haliza Abdul Mutalib Sharanjeet Sharanjeet-Kaur Ong Yi Lin Bashirah Ishak MohdNorhafizun Bin Mohd Saman Mohd Izzuddin Hairol 
AIM:To compare the Ishihara test errors scores of colour vision deficiency(CVD)subjects when wearing four different types of red-tinted contact lenses(RCL)that differ in their transmittance as determined using a spect...
关键词：anomalous trichromats colour vision deficiency contact lenses deutan protan 
Mutations in GTPBP3 cause aberrant mitochondrial respiration associated with combined oxidative phosphorylation deficiency 23
《Genes & Diseases》2025年第1期76-79,共4页Qianqian Li Yang Yang Ranran Li Chenguang Yu Kaidi Ren Yin Feng Xing Chen Yi Luan Xiangdong Kong 
supported by the National Natural Science Foundation of China(No.82000321,31900502);Henan Educational Committee Program for Science and Technology Development of Universities(China)(No.22A310022,24A320017);Natural Science Foundation of Henan,China(No.212300410275);Henan Medical Science and Technology Joint Building Program(China)(No.LHGJ20190229,LHGJ20190236,and LHGJ20230283);the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079,SBGJ202302045).
Combined oxidative phosphorylation deficiency 23(COXPD23,MIM#616198)is a rare autosomal-recessive mitochondrial disorder with variable disease severity ranging from death in early infancy to survival into the second d...
关键词：OXIDATIVE clinical CARDIOMYOPATHY 
Genetic feature diversity of KRAS-mutated colorectal cancer and the negative association of DNA mismatch repair deficiency relevant mutational signatures with prognosis
《Genes & Diseases》2025年第1期102-105,共4页Ruichuan Shi Yu Cheng Jin Wang Na Song Ying Chen Zan Teng Ling Xu Yunpeng Liu Xiaotian Zhao Qiuxiang Ou Peng Yang Rui Ma Yiting Sun Jinglei Qu Xiujuan Qu 
supported by grants from the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2017ZX09304025);the Technological Special Project of Liaoning Province,China(No.2019020176-JH1/103);the High-level innovation and entrepreneurship team of Liaoning province's"Xing Liao Talents Program"(No.XLYC2008006).
KRAS mutations occur in approximately 40%of metastatic colorectal cancer(CRC),leading to disrupted hydrolysis of guanosine triphosphate and tumor cell proliferation.1 Genetic features and clinical outcomes of CRCs dep...
关键词：KRAS COLORECTAL PROGNOSIS 
Interactions between Zn, Fe, Cu and Mn in Various Organs of Bread Wheat at Deficiency and Adequate of Absorbable Zinc
《American Journal of Plant Sciences》2025年第2期232-244,共13页Mohsen Niazkhani Azita Navvabi 
Deficiency or restriction of Zn absorption in soils is one of the most common micronutrients deficient in cereal plants. To investigate critical micronutrient interaction in zinc deficiency and zinc sufficient in soil...
关键词：Interaction MICRONUTRIENT Translocation Ratio Zn Deficiency Zn-Efficient 
Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptorα
《Genes & Diseases》2025年第1期312-326,共15页Guangfei Li Aifei Wang Wei Tang Wenyu Fu Qingyun Tian Jinlong Jian Michal Lata Aubryanna Hettinghouse Yuanjing Ding Jianlu Wei Xiangli Zhao Mingyong Wang Qirong Dong Chuanju Liu Youjia Xu 
supported by the grants from China Scholarship Council(No.201505320002);the National Institutes of Health(No.R01AR062207,R01AR061484,R01AR076900,R01NS103931);Young Medical Talents Program of Jiangsu Province,China(No.QNRC2016878);National Key R&D Program of China(No.SQ2021YFC2501702);Natural Science Foundation of China(No.82072474);Clinical Medicine Technology Project of Jiangsu Province,China(No.BE2019661).
Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis.However,the underlying mechanism is still not completely understood.In this study,progranulin(PGRN)was isolated as a key regula...
关键词：Estrogen receptorα OSTEOCLASTOGENESIS Postmenopausal osteoporosis Progranulin UBIQUITINATION 
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