DIHYDROTESTOSTERONE

作品数:22被引量:39H指数:4
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相关领域:医药卫生更多>>
相关作者:陈巧琴更多>>
相关机构:中国医学科学院北京协和医学院更多>>
相关期刊:《Journal of Cosmetics, Dermatological Sciences and Applications》《Chinese Journal of Natural Medicines》《Asian Journal of Traditional Medicines》《Pharmacology & Pharmacy》更多>>
相关基金:国家自然科学基金高等学校学科创新引智计划更多>>
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Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers
《Food Science and Human Wellness》2024年第6期3311-3324,共14页Hoon Kim Jongyeob Kim Byungdoo Hwang Sang Yong Park Ji-Yeon Shin Eun Byeol Go Jae Sil Kim Youngjin Roh Soon Chul Myung Seok-Joong Yun Yung Hyun Choi Wun-Jae Kim Sung-Kwon Moon 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2018R1A6A1A03025159).
Krill oil(KO)exhibits various biological activities,such as anti-inflammatory and antitumor effects.However,the inhibitory effects of benign prostatic hyperplasia(BPH)in vitro and in vivo have not yet been studied.Thi...
关键词:Proliferation G0/G1-phase cell cycle NF-κB DIHYDROTESTOSTERONE 
Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial被引量:1
《Food Science and Human Wellness》2023年第5期1917-1923,共7页Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang 
Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect ...
关键词:Banana flower DIHYDROTESTOSTERONE Hair loss ROS Follicle dermal papilla cells 
Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells
《Asian Journal of Andrology》2022年第5期513-520,共8页Yu Tong Yi-Jun Guo Qin Zhang Hai-Xia Bi Kai Kai Ren-Yuan Zhou 
This study was funded by Shanghai Jing’an Science and Technology Commission(grant No.2020MS04).
Androgens and chronic inflammation,which play essential roles in the development of benign prostatic hyperplasia(BPH),are considered to be important factors in disorders of prostate homeostasis.These two factors may l...
关键词:benign prostatic hyperplasia DIHYDROTESTOSTERONE inflammation macrophage tumor necrosis factor-alpha 
Polyphenol-Rich Olive Mill Wastewater Extract and Its Potential Use in Hair Care Products被引量:1
《Journal of Cosmetics, Dermatological Sciences and Applications》2021年第4期356-370,共15页Lisa-Marie Sittek Thomas M. Schmidts Peggy Schlupp 
In this work, the influence of phenol-enriched olive mill wastewater (OMWW) extract on hair growth was investigated in vitro on human follicle dermal papilla cells. OMWW has already shown great potential for ...
关键词:Hair Growth Hair Loss Human Follicle Dermal Papilla Cells CAFFEINE DIHYDROTESTOSTERONE IGF-1 VEGF Reactive Oxygen Species 
High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors
《Asian Journal of Traditional Medicines》2021年第4期216-224,共9页Ruirong Zheng Mooseob Kim Zhengtao Wang Li Yang 
This study was financially supported by the Program of Shanghai Municipal Commission of Health and Family Planning(ZY(2018-2020)-CCCX-5002).
Benign prostatic hyperplasia(BPH)is a common disease in men,and is known to be related to 5α-reductase,which can affect steroid metabolism.Under the promotion of 5α-reductase,testosterone can be converted into dihyd...
关键词:5α-reductase inhibitor benign prostatic hyperplasia HPTLC steroid hormones DIHYDROTESTOSTERONE 
Effect of Dihydrotestosterone on Costimulatory Molecules in a Mouse Model of Graves’ Disease
《Chinese Medical Sciences Journal》2020年第3期215-225,共11页Lianye Liu Bingyin Shi Fengyi Zhao Peng Hou Shu Liu Xiaomei Liu Liping Wu 
supported by the National Natural Science Foundation(grant number 81670725,2017.01-2020.12);Key Research and Development Project of Shaanxi Province(grant number 2017ZDXM-SF-060,2017.01-2019.12)。
Objective Graves’disease is the most common autoimmune thyroid disease and its prevalence and clinical manifestations are disparate between females and males.Costimulatory molecules play an essential role in regulati...
关键词:Graves’disease 5α-dihydrotestosterone costimulatory molecules inhibitory molecules 
Identification of three novel SRD5A2 mutations in Chinese patients with 5α-reductase 2 deficiency被引量:4
《Asian Journal of Andrology》2019年第6期577-581,共5页Tong Cheng Hao Wang Bing Han Hui Zhu Hai-Jun Yao Shuang-Xia Zhao Wen-Jiao Zhu Hua-Ling Zhai Fu-Guo Chen Huai-Dong Song Kai-Xiang Cheng Yang Liu Jie Qiao 
This study is supported by grants from the National Natural Science Foundation(No.81570753,81430019 and 81873652);the Shanghai Jiao Tong University Medical and Engineering Intersection Foundation(No.YG2015QN03).
In this study,we investigated the genetics,clinical features,and therapeutic approach of 14 patients with 5a-reductase deficiency in China.Genotyping analysis was performed by direct sequencing of PCR products of the ...
关键词:5a-reductase type 2 DEFICIENCY DIHYDROTESTOSTERONE MUTATION SRD5A2 
The Efficacy of Ostrich Antibodies to Dihydrotestosterone and 5<i>α</i>-Reductase in the Restoration of Hair Growth被引量:1
《Health》2019年第10期1320-1330,共11页Yasuhiro Tsukamoto Barry Hendler Stuart Greenberg Carol Epstein 
The hormone dihydro testosterone (DHT) and the catalyst 5α-reductase are key contributors to hair loss due to androgenetic alopecia (AGA). Also, dermal bacteria and their toxins have been implicated in hair loss. A p...
关键词:ALOPECIA AGA OSTRICH Antibody 
Potential impact of combined inhibition of 3a-oxidoreductases and 5a-reductases on prostate cancer被引量:2
《Asian Journal of Urology》2019年第1期50-56,共7页Michael V.Fiandalo Daniel T.Gewirth James L.Mohler 
This study was supported by the DoD Prostate Cancer Research Program Award(No.W81XWH-16-1-0635);the National Cancer Institute(NO.P01CA77739 and NO.R21CA205108)to James L.Mohler;Post-doctoral Training Award(No.W81XWH-15-1-0409)to Michael V.Fiandalo;DoD Synergistic Idea Development Award(No.W81XWH-14-1-0520)to Dan T.Gewirth;NCI Cancer Center Support Grant to Roswell Park Comprehensive Cancer Center for the Bioanalytics,Metabolomics and Pharmacokinetics,Pathology Network,and Genomics Shared Resources(No.P30CA016056).
Prostate cancer(PCa)growth and progression rely on the interaction between the androgen receptor(AR)and the testicular ligands,testosterone and dihydrotestosterone(DHT).Almost all men with advanced PCa receive androge...
关键词:Androstanediol DIHYDROTESTOSTERONE DUTASTERIDE 3a-oxidoreductases Androgen deprivation therapy ABIRATERONE 
Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury被引量:2
《Neural Regeneration Research》2018年第6期971-976,共6页Dale R.Sengelaub Xiao-Ming Xu 
supported by grants from Indiana Spinal Cord and Brain Injury Research Fund(ISCBIRF);by IU’s Office of the Vice Provost for Research through the Faculty Research Support Program to DRS;NIH R01 NS103481,R01 NS100531;Department of Veterans Affairs I01 RX002356,I01 BX003705;Craig H Neilsen Foundation 296749,Indiana Department of Health 019919,ISCBIRF;Mari Hulman George Endowment Fund to XMX
Spinal cord injury(SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. The majority of treatment strategies after SCI have concentrated on t...
关键词:TESTOSTERONE DIHYDROTESTOSTERONE ESTRADIOL STEROIDS ATROPHY neuroprotection morphology DENDRITES muscle fibers retrograde labeling 
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