Polyphenol-Rich Olive Mill Wastewater Extract and Its Potential Use in Hair Care Products  

作　　者：Lisa-Marie Sittek Thomas M. Schmidts Peggy Schlupp Lisa-Marie Sittek;Thomas M. Schmidts;Peggy Schlupp(RSC Pharma GmbH & Co. KG, Giessen, Germany)

机构地区：[1]RSC Pharma GmbH & Co. KG, Giessen, Germany

出　　处：《Journal of Cosmetics, Dermatological Sciences and Applications》2021年第4期356-370,共15页化妆品、皮肤病及应用期刊（英文）

摘　　要：In this work, the influence of phenol-enriched olive mill wastewater (OMWW) extract on hair growth was investigated <em>in vitro</em> on human follicle dermal papilla cells. OMWW has already shown great potential for use in skincare products, and its high polyphenol content is predestined to have a positive effect on hair growth. The studies included caffeine, a positive modulator of hair growth, and dihydrotestosterone, which causes hair loss <em>in vivo</em>, as controls. The impact of the investigated compounds on hair growth was evaluated by studies on cell viability and proliferation, the release of growth factors (insulin-like growth factor-1 and vascular endothelial growth factor), and the reduction of reactive oxygen species formation. OMWW showed a positive influence on the proliferation of the human follicle dermal papilla cells. Moreover, the extract leads to a significantly increased secretion of insulin-like growth factor-1, and a considerable reduction in reactive oxygen species formation was observed. Overall, our results show that the investigated phenol-enriched OMWW extract is a promising ingredient for hair care to improve hair growth, prevent hair loss due to oxidative stress and maintain a healthy scalp.In this work, the influence of phenol-enriched olive mill wastewater (OMWW) extract on hair growth was investigated <em>in vitro</em> on human follicle dermal papilla cells. OMWW has already shown great potential for use in skincare products, and its high polyphenol content is predestined to have a positive effect on hair growth. The studies included caffeine, a positive modulator of hair growth, and dihydrotestosterone, which causes hair loss <em>in vivo</em>, as controls. The impact of the investigated compounds on hair growth was evaluated by studies on cell viability and proliferation, the release of growth factors (insulin-like growth factor-1 and vascular endothelial growth factor), and the reduction of reactive oxygen species formation. OMWW showed a positive influence on the proliferation of the human follicle dermal papilla cells. Moreover, the extract leads to a significantly increased secretion of insulin-like growth factor-1, and a considerable reduction in reactive oxygen species formation was observed. Overall, our results show that the investigated phenol-enriched OMWW extract is a promising ingredient for hair care to improve hair growth, prevent hair loss due to oxidative stress and maintain a healthy scalp.

关 键 词：Hair Growth Hair Loss Human Follicle Dermal Papilla Cells CAFFEINE DIHYDROTESTOSTERONE IGF-1 VEGF Reactive Oxygen Species 

分 类 号：X70[环境科学与工程—环境工程]