High performance thin layer chromatography as an effective tool for rapid screening of 5α-reductase inhibitors  

作　　者：Ruirong Zheng Mooseob Kim Zhengtao Wang Li Yang 

机构地区：[1]The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [2]Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Asian Journal of Traditional Medicines》2021年第4期216-224,共9页亚洲传统医药（英文）

基　　金：This study was financially supported by the Program of Shanghai Municipal Commission of Health and Family Planning(ZY(2018-2020)-CCCX-5002).

摘　　要：Benign prostatic hyperplasia(BPH)is a common disease in men,and is known to be related to 5α-reductase,which can affect steroid metabolism.Under the promotion of 5α-reductase,testosterone can be converted into dihydrotestosterone(DHT),and excessive DHT will cause related diseases.Since BPH seriously affects the quality of life of patients,it is essential to discover effective 5α-reductase inhibitors.In this study,the simple analytical method of high performance thin layer chromatography(HPTLC)was used to screen active compounds,and seven compounds with strong activity were screened out.This research will provide a reference for studying the material basis of drugs for the treatment of BPH.

关 键 词：5α-reductase inhibitor benign prostatic hyperplasia HPTLC steroid hormones DIHYDROTESTOSTERONE 

分 类 号：R69[医药卫生—泌尿科学]