SR蛋白家族对肿瘤发生发展影响的研究进展  

Research Progress on Effect of SR Protein Family on Tumor Occurrence and Development

作　　者：李梦仙 俞建昆[2] 温艳萍 吴翰欣 高凌[1] 刘晓晓 邰文琳[1] LI Mengxian;YU Jiankun;WEN Yanping;WU Hanxin;GAO Ling;LIU Xiaoxiao;TAI Wenlin(Second Affiliated Hospital of Kunming Medical University,Kunming 650118,China;不详)

机构地区：[1]昆明医科大学附属第二医院,云南昆明650118 [2]中国医学科学院医学生物学研究所

出　　处：《中国医学创新》2020年第15期169-172,共4页Medical Innovation of China

基　　金：国家自然科学基金(81760383);昆明医科大学研究生创新基金资助项目(2019S152)。

摘　　要：SR(serine/arginine-rich protein)蛋白作为反式作用因子的一类,通过与顺式作用元件的结合来调控选择性剪接。近年来的研究发现,SR蛋白家族不同成员在许多肿瘤中表达量存在显著差异,通过调控肿瘤相关基因的选择性剪接过程从而影响肿瘤的发生发展。本文就近年来已有文献报道的SR蛋白家族部分成员在不同肿瘤疾病进展过程中所发挥的作用及机制简要做一综述。SR(serine/arginine-rich protein)protein,as a class of important splicing factors,plays an important role in the formation of mature mRNA by alternative splicing of precursor mRNA(pre-mRNA).In recent years,studies have found that SR protein family had significant differences in the expression of many tumors,and it affects the occurrence and development of tumors by regulating the alternative splicing process of tumor-related genes.In this paper,the role and mechanism of some members of the SR protein family reported in recent literature in the progression of different tumor diseases are briefly reviewed.

关 键 词：选择性剪接 SR蛋白 剪接因子 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]